AZ32
- Product Name
- AZ32
- CAS No.
- 2288709-96-4
- Chemical Name
- AZ32
- Synonyms
- AZ32;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
- CBNumber
- CB28095233
- Molecular Formula
- C20H16N4O
- Formula Weight
- 328.37
- MOL File
- 2288709-96-4.mol
AZ32 Property
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 150 mg/ml
- form
- A solid
- pka
- 14.63±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2551
- Product name
- AZ32
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $128
- Updated
- 2024/03/01
- Product number
- SML2551
- Product name
- AZ32
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $494
- Updated
- 2024/03/01
- Product number
- 26380
- Product name
- AZ 32
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 26380
- Product name
- AZ 32
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 26380
- Product name
- AZ 32
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
AZ32 Chemical Properties,Usage,Production
Biological Activity
AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM.
in vitro
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
in vivo
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours.
AZ32 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ32 Suppliers
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