SH-5
- Product Name
- SH-5
- CAS No.
- 701976-54-7
- Chemical Name
- SH-5
- Synonyms
- SH-5;PIA 5;AKT INHIBITOR II;SH-5, Akt inhibitor;D-3-DEOXY-2-O-METHYL-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE];1-Deoxy-6-O-methyl-L-chiro-inositol 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II
- CBNumber
- CB2816485
- Molecular Formula
- C29H59O10P
- Formula Weight
- 598.75
- MOL File
- 701976-54-7.mol
SH-5 Property
- storage temp.
- -20°C
- solubility
- DMSO: 10mg/mL
- form
- solid
- color
- white
N-Bromosuccinimide Price
- Product number
- MP59676
- Product name
- Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol)
- Packaging
- 1mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- INB0002701
- Product name
- D-3-DEOXY-2-O-METHYL-MYO-INOSITOL-1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE]
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.92
- Updated
- 2021/12/16
- Product number
- MP59676
- Product name
- Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol)
- Packaging
- 2mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 6704CR
- Product name
- (2-Methoxy-3-octadecoxypropyl)(2,3,4-trihydroxy-6-methoxycyclohexyl)hydrogenphosphate
- Packaging
- 2mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- MP59676
- Product name
- Phosphatidyl 1-(3-deoxy-2-O-methyl-D-myo-inositol)
- Packaging
- 5mg
- Price
- $975
- Updated
- 2021/12/16
SH-5 Chemical Properties,Usage,Production
Uses
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].
Biological Activity
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes
Enzyme inhibitor
This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics.
References
[1] Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. DOI:10.1016/j.bcp.2008.05.023
SH-5 Preparation Products And Raw materials
Raw materials
Preparation Products
SH-5 Suppliers
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