SH-6
- Product Name
- SH-6
- CAS No.
- 701976-55-8
- Chemical Name
- SH-6
- Synonyms
- SH-6;PIA 6;AKT INHIBITOR III;SH 6 (enzyme inhibitor);D-2,3-DIDEOXY-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE];D-2,3-Dideoxy-2-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];Phosphoric acid, mono[(2R)-2-methoxy-3-(octadecyloxy)propyl] mono[(1R,2R,3S,4R)-2,3,4-trihydroxycyclohexyl] ester
- CBNumber
- CB6298265
- Molecular Formula
- C28H57O9P
- Formula Weight
- 568.72
- MOL File
- 701976-55-8.mol
SH-6 Property
- storage temp.
- -20°C
- solubility
- DMSO: 10mg/mL
- form
- solid
- color
- white
Safety
- WGK Germany
- WGK 1
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- S1010-74A
- Product name
- SH-6
- Packaging
- 500ug
- Price
- $462
- Updated
- 2021/12/16
- Product number
- MP59677
- Product name
- Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol)
- Packaging
- 2mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- INB0002700
- Product name
- D-2,3-DIDEOXY-MYO-INOSITOL-1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE]
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.36
- Updated
- 2021/12/16
- Product number
- MP59677
- Product name
- Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol)
- Packaging
- 5mg
- Price
- $975
- Updated
- 2021/12/16
- Product number
- 2791CS
- Product name
- [(2R)-2-Methoxy-3-octadecoxypropyl][(1R,2R,3S,4R)-2,3,4-trihydroxycyclohexyl]hydrogenphosphate
- Packaging
- 5mg
- Price
- $1366
- Updated
- 2021/12/16
SH-6 Chemical Properties,Usage,Production
Uses
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
Biological Activity
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes
SH-6 Preparation Products And Raw materials
Raw materials
Preparation Products
SH-6 Suppliers
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
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- China
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- 400-001-2615 13691409741
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- 21-20338288
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- 51288865780
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- tp@aladdinsci.com
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