DERAMCICLANE
- Product Name
- DERAMCICLANE
- CAS No.
- 120444-71-5
- Chemical Name
- DERAMCICLANE
- Synonyms
- EGIS-3886;DERAMCLCLANE;DERAMCICLANE;DERAMCICLANE ISO 9001：2015 REACH;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
- CBNumber
- CB2818661
- Molecular Formula
- C20H31NO
- Formula Weight
- 301.47
- MOL File
- 120444-71-5.mol
DERAMCICLANE Property
- Boiling point:
- 375.2±25.0 °C(Predicted)
- Density
- 1.01±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
N-Bromosuccinimide Price
- Product number
- API0007969
- Product name
- DERAMCICLANE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.31
- Updated
- 2021/12/16
- Product number
- CSN21600
- Product name
- Deramciclane
- Packaging
- 25mg
- Price
- $1225
- Updated
- 2021/12/16
- Product number
- CSN21600
- Product name
- Deramciclane
- Packaging
- 1mg
- Price
- $204
- Updated
- 2021/12/16
DERAMCICLANE Chemical Properties,Usage,Production
in vitro
Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are further characterized using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.
in vivo
Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C < /sub> receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.
DERAMCICLANE Preparation Products And Raw materials
Raw materials
Preparation Products
DERAMCICLANE Suppliers
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- Country
- United States
- ProdList
- 19892
- Advantage
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- United States
- ProdList
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