ChemicalBook > CAS DataBase List > 1,3-BENZODIOXOL-4-AMINE

1,3-BENZODIOXOL-4-AMINE

Product Name: 1,3-BENZODIOXOL-4-AMINE
CAS No.: 1668-84-4
Chemical Name: 1,3-BENZODIOXOL-4-AMINE
Synonyms: 1,3-BENZODIOXOL-4-AMINE;2,3-Methylenedioxyaniline;2H-1,3-benzodioxol-4-aMine;benzo[d][1,3]dioxol-4-amine;Aniline, 2,3-(methylenedioxy)-
CBNumber: CB2839927
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 1668-84-4.mol

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1,3-BENZODIOXOL-4-AMINE Property

Melting point:: 32-33 °C(Solv: hexane (110-54-3))
Boiling point:: 100-105 °C(Press: 0.09 Torr)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: powder
pka: 4.12±0.20(Predicted)
color: Brown
InChI: InChI=1S/C7H7NO2/c8-5-2-1-3-6-7(5)10-4-9-6/h1-3H,4,8H2
InChIKey: KQMXPHISFRKBJP-UHFFFAOYSA-N
SMILES: O1C2=CC=CC(N)=C2OC1

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B200065
Product name: 1,3-Benzodioxol-4-amine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B200065
Product name: 1,3-Benzodioxol-4-amine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Usbiological

Product number: 410939
Product name: 1,3-Benzodioxol-4-amine
Packaging: 25mg
Price: $305
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154280
Product name: 1,3-Benzodioxol-4-amine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154280
Product name: 1,3-Benzodioxol-4-amine
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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1,3-BENZODIOXOL-4-AMINE Chemical Properties,Usage,Production

Synthesis

111081-10-8

1668-84-4

The general procedure for the synthesis of 4-amino-1,3-benzodioxole from tert-butyl benzo[d][1,3]dioxol-4-ylcarbamate was as follows: the Boc-protected feedstock G2 (257 mg, 1.08 mmol) was dissolved in a dioxane solution (5.0 mL) of 4 M HCl and stirred for 1 h at room temperature. Upon completion of the reaction, the solvent was removed by evaporation and the residue was diluted with saturated sodium bicarbonate solution (a few milliliters) and 1 M NaOH solution (1 mL), followed by extraction with ethyl acetate (EtOAc, 2×). The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO?), filtered and evaporated to dryness to afford the crude product 2,3-methylenedioxypropane G3 (158 mg, 106% yield).

References

[1] Patent: WO2004/103996, 2004, A1. Location in patent: Page 50
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991, # 2, p. 259 - 262
[4] Patent: US2004/34046, 2004, A1
[5] Patent: WO2004/4732, 2004, A1. Location in patent: Page/Page column 66

1,3-BENZODIOXOL-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3-BENZODIOXOL-4-AMINE manufacturers

Career Henan Chemical Co

Product: 1,3-BENZODIOXOL-4-AMINE 1668-84-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1668-84-4, 1,3-BENZODIOXOL-4-AMINERelated Search:

MELICOPINE 1-BENZO[1,3]DIOXOL-4-YL-PIPERAZINE BENZO[1,3]DIOXOL-4-METHYLAMINE 5-(6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-BENZO[1,3]DIOXOL-4-YLAMINE 4-Amino-2,2-difluoro-1,3-benzodioxole 5-BROMO-1,3-BENZODIOXOL-4-AMINE O-NITROPIPERONAL Saracatinib TERT-BUTYL 1,3-BENZODIOXOL-4-YLCARBAMATE 5-CHLORO-1,3-BENZODIOXOL-4-AMINE TERT-BUTYL (5-FLUORO-1,3-BENZODIOXOL-4-YL)CARBAMATE 5-FLUORO-1,3-BENZODIOXOL-4-AMINE 1,3-BENZODIOXOL-4-AMINE TERT-BUTYL (5-BROMO-1,3-BENZODIOXOL-4-YL)CARBAMATE 2,2-Difluoro-8H-1,3-dioxa-8-aza- as-indacene-6,7-dione TERT-BUTYL (5-CHLORO-1,3-BENZODIOXOL-4-YL)CARBAMATE

1,3-BENZODIOXOL-4-AMINE

benzo[d][1,3]dioxol-4-amine

2H-1,3-benzodioxol-4-aMine

2,3-Methylenedioxyaniline

Aniline, 2,3-(methylenedioxy)-

1668-84-4