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IL-17A inhibitor 1

Product Name
IL-17A inhibitor 1
CAS No.
2452464-73-0
Chemical Name
IL-17A inhibitor 1
Synonyms
LY3509754;LY-3533028;IL-17A inhibitor 1;IL-17A inhibitor 1, 10 mM in DMSO;inhibit,Inhibitor,Interleukin Related,COPD,Asthma,IL-17A inhibitor 1,IL17A inhibitor 1,IL 17A inhibitor 1;1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
CBNumber
CB28529477
Molecular Formula
C24H27F5N8O4
Formula Weight
586.51
MOL File
2452464-73-0.mol
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IL-17A inhibitor 1 Property

Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
11.52±0.46(Predicted)
form 
Solid
color 
Off-white to yellow
InChIKey
MVWVCLAORBNXSD-UWVAXJGDSA-N
SMILES
O1N=C(C)C(C(N[C@@H](C2CCC(F)(F)CC2)C2=CN3C(=N2)C=C([C@H](N2C(=O)N[C@H](C(F)(F)F)C2)COC)C=N3)=O)=N1
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Hazard and Precautionary Statements (GHS)

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IL-17A inhibitor 1 Chemical Properties,Usage,Production

Uses

LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1].

Biological Activity

IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1]. IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%)[1].

in vivo

LY3509754 (example 24) possesses high oral bioavailability (F=107%)[1].

IC 50

IL-17

References

[1]. COATES DAVID ANDREW, et al. IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS. Patent WO2020146194.

IL-17A inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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IL-17A inhibitor 1 Suppliers

China 28 United States 3 Global 31
TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
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China
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24961
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Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
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0550-5196001
Email
wj520wjxby@126.com
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China
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1944
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4757
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55
ShangHai Angti Biotechnology Co., Ltd.
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13764913901
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info@angtibio.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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2988
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Kaixin Chemical (Hong Kong) Limited
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010-88886666-01 13112345678
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CDXH21@126.com
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loyson@tcypharm.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
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15317229551
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QQ:3607245178
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15151849396@163.com
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China
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989
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58
Chunchuang (Wuhan) Technology Co., Ltd
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15727060112
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yutianchun2007@126.com
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China
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9814
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2452464-73-0, IL-17A inhibitor 1Related Search:


  • 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
  • LY-3533028
  • IL-17A inhibitor 1
  • inhibit,Inhibitor,Interleukin Related,COPD,Asthma,IL-17A inhibitor 1,IL17A inhibitor 1,IL 17A inhibitor 1
  • IL-17A inhibitor 1, 10 mM in DMSO
  • LY3509754
  • 2452464-73-0
  • C24H27F5N8O4