ChemicalBook > CAS DataBase List > IL-17A inhibitor 1
IL-17A inhibitor 1
- Product Name
- IL-17A inhibitor 1
- CAS No.
- 2452464-73-0
- Chemical Name
- IL-17A inhibitor 1
- Synonyms
- LY3509754;LY-3533028;IL-17A inhibitor 1;IL-17A inhibitor 1, 10 mM in DMSO;inhibit,Inhibitor,Interleukin Related,COPD,Asthma,IL-17A inhibitor 1,IL17A inhibitor 1,IL 17A inhibitor 1;1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
- CBNumber
- CB28529477
- Molecular Formula
- C24H27F5N8O4
- Formula Weight
- 586.51
- MOL File
- 2452464-73-0.mol
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IL-17A inhibitor 1 Property
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 11.52±0.46(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChIKey
- MVWVCLAORBNXSD-UWVAXJGDSA-N
- SMILES
- O1N=C(C)C(C(N[C@@H](C2CCC(F)(F)CC2)C2=CN3C(=N2)C=C([C@H](N2C(=O)N[C@H](C(F)(F)F)C2)COC)C=N3)=O)=N1
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IL-17A inhibitor 1 Chemical Properties,Usage,Production
Uses
LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1].
Biological Activity
IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1]. IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%)[1].
in vivo
LY3509754 (example 24) possesses high oral bioavailability (F=107%)[1].
IC 50
IL-17
References
[1]. COATES DAVID ANDREW, et al. IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS. Patent WO2020146194.
IL-17A inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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IL-17A inhibitor 1 Suppliers
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