ergotamine
- Product Name
- ergotamine
- CAS No.
- 113-15-5
- Chemical Name
- ergotamine
- Synonyms
- ergotamin;NSC 95090;ergotamine;Ergotamine (8CI);ergotamine USP/EP/BP;XCGSFFUVFURLIX-VFGNJEKYSA-N;12'-Hydroxy-2'-methyl-5'α-benzylergotaman-3',6',18-trione;12’-hydroxy-2’-methyl-5’alpha-(phenylmethyl)ergotaman-3’,6’,18-trione;6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’-alph;18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-6(5’alpha)-ergotaman-3
- CBNumber
- CB2865180
- Molecular Formula
- C33H35N5O5
- Formula Weight
- 581.66
- MOL File
- 113-15-5.mol
ergotamine Property
- Melting point:
- 241-249℃
- alpha
- D20 -160° (chloroform)
- Boiling point:
- 651.33°C (rough estimate)
- Density
- 1.0998 (rough estimate)
- refractive index
- 1.7500 (estimate)
- pka
- pKa 6.40±0.09(H2O t=24.0) (Uncertain)
- CAS DataBase Reference
- 113-15-5
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 113-15-5(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats, rabbits (mg/kg): 62, 80, 3 i.v.; in cats: 11 s.c. (Rothlin)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H330Fatal if inhaled
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
ergotamine Chemical Properties,Usage,Production
Uses
Analgesic (specific in migraine).
Uses
Ergotamine, 3′,6′,18′-trione,12′-hydroxy-2′-methyl-5′-benzyl-(5α)-ergotamine (12.2.14), is obtained via microbiological synthesis [52].As an α-adrenoblocker, ergotamine exhibits a direct vasoconstricting effect for which it is used in medicine, particularly for alleviation of severe migraine attacks. It is categorically counterproductive in chronic diseases because of the possibility of side effects such as triggering gangrene.
Definition
ChEBI: A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.
brand name
Ergomar (Harvest);Ergostat (Parke-Davis); Wigrettes (Organon).
Purification Methods
Crystallise it from *benzene, then dry it by prolonged heating in high vacuum. It is very hygroscopic. [Beilstein 25 III/IV 964.]