Ethyl Biscoumacetate
- Product Name
- Ethyl Biscoumacetate
- CAS No.
- 548-00-5
- Chemical Name
- Ethyl Biscoumacetate
- Synonyms
- Trombil;Pelentan;Trombarin;Trombolysan;Ethyl Biscoumacetate;DI(4-oxi-cymarinyl-3);Ethyl Biscoumacetate USP/EP/BP;ethyl bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate;ethyl 2,2-bis(2-hydroxy-4-oxochromen-3-yl)acetate;ethyl 2,2-bis(2-hydroxy-4-oxo-chromen-3-yl)ethanoate
- CBNumber
- CB2875406
- Molecular Formula
- C22H16O8
- Formula Weight
- 408.36
- MOL File
- 548-00-5.mol
Ethyl Biscoumacetate Property
- Melting point:
- 177-182° and mp 154-157°
- Boiling point:
- 448.92°C (rough estimate)
- Density
- 1.3259 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- pKa 7.5 (Uncertain)
- color
- White
- Water Solubility
- 54.31mg/L(temperature not stated)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 in mice, rats (g/kg): 0.88, 0.26 orally; 0.32, 1.1 i.p. (Gruber)
N-Bromosuccinimide Price
- Product number
- E900100
- Product name
- EthylBiscoumacetate
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FRL0000102
- Product name
- ETHYL BISCOUMACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $236.25
- Updated
- 2021/12/16
- Product number
- BBC/596
- Product name
- ethylbis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
Ethyl Biscoumacetate Chemical Properties,Usage,Production
Chemical Properties
White, crystalline solid; odorless; bitter taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.
Originator
Tromexan,Geigy,US,1950
Uses
Anticoagulant.
Uses
Medicine (anticoagulant).
Definition
A synthetic derivative of bishydroxycoumarin.
Manufacturing Process
7 g of benzotetronic acid are dissolved in 750 cc of water at boiling
temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl
alcoholate are added. After a short while the liquid becomes turbid and
gradually a white deposit is separated. The deposit is filtrated and dried in
vacuo. The melting point is 172°C to 174°C; after recrystallization from
methyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animal
charcoal precipitated by means of hydrochloric acid, and recrystallized from
methyl alcohol. The melting point is 153°C to 154°C.
Therapeutic Function
Anticoagulant
Synthesis
Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy- 3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.
Ethyl Biscoumacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl Biscoumacetate manufacturers
- Product
- Ethyl Biscoumacetate 548-00-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-04