metipranolol

Product Name: metipranolol
CAS No.: 22664-55-7
Chemical Name: metipranolol
Synonyms: Disorat;Glausyn;Glauline;VUFB-6453;Trimepranol;Methypranol;4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE;4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethylphenol 1-acetate;Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate;stress,Metipranolol,Beta Receptor,glaucoma,lipid,Adrenergic Receptor,antioxidant,peroxidation,inhibit,Nitrosative,Inhibitor,hypertension
CBNumber: CB2880767
Molecular Formula: C17H27NO4
Formula Weight: 309.4
MOL File: 22664-55-7.mol

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metipranolol Property

Melting point:: 105-107℃
Boiling point:: 458.7±45.0 °C(Predicted)
Density: 1.068
storage temp.: 4°C, protect from light
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: 13.91±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3
InChIKey: BQIPXWYNLPYNHW-UHFFFAOYSA-N
SMILES: C1(OC(=O)C)=C(C)C=C(OCC(O)CNC(C)C)C(C)=C1C

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Safety

Toxicity: LD50 in mice (mg/kg): 31 i.v. (Bartsch)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R736139
Product name: 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP642
Product name: Metipranolol
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100 mg
Price: $286
Updated: 2025/07/31

Sigma-Aldrich

Product number: R736139
Product name: 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE
Purity: Aldrich
Packaging: 10mg
Price: $139
Updated: 2024/03/01

ChemScene

Product number: CS-0082752
Product name: Metipranolol
Purity: 98.36%
Packaging: 50mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0082752
Product name: Metipranolol
Purity: 98.36%
Packaging: 100mg
Price: $620
Updated: 2021/12/16

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metipranolol Chemical Properties,Usage,Production

Uses

Antihypertensive (β-blocker, ophthalmic).

Definition

ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl glaucoma.

brand name

OptiPranolol (Bausch & Lomb Pharmaceuticals).

in vivo

At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice^[1].

IC 50

β1 adrenoceptor: 8.3 (pA2); β2 adrenoceptor: 8.4 (pA2)

metipranolol Preparation Products And Raw materials

Raw materials

Preparation Products

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metipranolol Suppliers

Austria 1 China 22 Europe 2 France 1 Russia 1 South Korea 1 United Kingdom 1 United States 7 Global 36

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22664-55-7, metipranololRelated Search:

2,3,6-Trimethylphenol MetipranololHydrochloride metipranolol SALOR-INT L128228-1EA SALOR-INT L129194-1EA SALOR-INT L129933-1EA SALOR-INT L129070-1EA

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethylphenol 1-acetate

Disorat

Methypranol

Trimepranol

VUFB-6453

Glauline

Glausyn

4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE

Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate

stress,Metipranolol,Beta Receptor,glaucoma,lipid,Adrenergic Receptor,antioxidant,peroxidation,inhibit,Nitrosative,Inhibitor,hypertension

22664-55-7

C17H27NO4