metipranolol
- Product Name
- metipranolol
- CAS No.
- 22664-55-7
- Chemical Name
- metipranolol
- Synonyms
- Disorat;Glausyn;Glauline;VUFB-6453;Trimepranol;Methypranol;4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE;4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethylphenol 1-acetate;Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate;stress,Metipranolol,Beta Receptor,glaucoma,lipid,Adrenergic Receptor,antioxidant,peroxidation,inhibit,Nitrosative,Inhibitor,hypertension
- CBNumber
- CB2880767
- Molecular Formula
- C17H27NO4
- Formula Weight
- 309.4
- MOL File
- 22664-55-7.mol
metipranolol Property
- Melting point:
- 105-107℃
- Boiling point:
- 458.7±45.0 °C(Predicted)
- Density
- 1.068
- storage temp.
- 4°C, protect from light
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 13.91±0.20(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3
- InChIKey
- BQIPXWYNLPYNHW-UHFFFAOYSA-N
- SMILES
- C1(OC(=O)C)=C(C)C=C(OCC(O)CNC(C)C)C(C)=C1C
Safety
- Toxicity
- LD50 in mice (mg/kg): 31 i.v. (Bartsch)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- R736139
- Product name
- 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $143
- Updated
- 2025/07/31
- Product number
- BP642
- Product name
- Metipranolol
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100 mg
- Price
- $286
- Updated
- 2025/07/31
- Product number
- R736139
- Product name
- 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE
- Purity
- Aldrich
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- CS-0082752
- Product name
- Metipranolol
- Purity
- 98.36%
- Packaging
- 50mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- CS-0082752
- Product name
- Metipranolol
- Purity
- 98.36%
- Packaging
- 100mg
- Price
- $620
- Updated
- 2021/12/16
metipranolol Chemical Properties,Usage,Production
Uses
Antihypertensive (β-blocker, ophthalmic).
Definition
ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl glaucoma.
brand name
OptiPranolol (Bausch & Lomb Pharmaceuticals).
in vivo
At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice[1].
IC 50
β1 adrenoceptor: 8.3 (pA2); β2 adrenoceptor: 8.4 (pA2)
metipranolol Preparation Products And Raw materials
Raw materials
Preparation Products
metipranolol Suppliers
- Tel
- --
- Fax
- --
- contact@ambinter.com
- Country
- France
- ProdList
- 1648
- Advantage
- 60