Thalidomide-O-PEG3-amine HCl

Product Name: Thalidomide-O-PEG3-amine HCl
CAS No.: 2387510-82-7
Chemical Name: Thalidomide-O-PEG3-amine HCl
Synonyms: 4-(H2N-PEG4)-Thalidomide HCl;Thalidomide-O-PEG3-amine HCl;Thalidomide-PEG4-NH2, HCl salt;Thalidomide 4'-ether-PEG3-amine;Thalidomide-PEG4-NH2 (hydrochloride);Thalidomide-O-PEG3-amine hydrochloride;4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;1H-Isoindole-1,3(2H)-dione, 4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CBNumber: CB29023930
Formula Weight: 485.92
MOL File: 2387510-82-7.mol

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Thalidomide-O-PEG3-amine HCl Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-PEG3-amine HCl Chemical Properties,Usage,Production

Uses

Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Thalidomide 4'-ether-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11

IC 50

Cereblon

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Thalidomide-O-PEG3-amine HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-PEG3-amine HCl Suppliers

China 12 United States 1 Global 13

Shanghai YuanYe Biotechnology Co., Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Xianning Shen Lan Biomedical Research and Development Co., Ltd.

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Shanghai Easy CDMO Co.,Ltd

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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Jilin Chinese Academy of Sciences-yanshen Technology

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Amatek Scientific Co. Ltd.

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R&D Systems, Inc

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View Lastest Price from Thalidomide-O-PEG3-amine HCl manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-PEG3-amine hydrochloride 2387510-82-7
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

2387510-82-7, Thalidomide-O-PEG3-amine HClRelated Search:

Thalidomide-4-O-C8-NH2 Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-amine Thalidomide-O-PEG4-NHS ester 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-azide

Thalidomide-O-PEG3-amine HCl

Thalidomide-PEG4-NH2 (hydrochloride)

Thalidomide-O-PEG3-amine hydrochloride

4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

Thalidomide-PEG4-NH2, HCl salt

1H-Isoindole-1,3(2H)-dione, 4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

Thalidomide 4'-ether-PEG3-amine

4-(H2N-PEG4)-Thalidomide HCl

2387510-82-7