Thalidomide-O-PEG4-NHS ester

Product Name: Thalidomide-O-PEG4-NHS ester
CAS No.: 2411681-88-2
Chemical Name: Thalidomide-O-PEG4-NHS ester
Synonyms: Thalidomide-O-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxapentadecan-15-oate;(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate;2,5-dioxopyrrolidin-1-yl 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}-3,6,9,12-tetraoxapentadecan-15-oate;2,5-Dioxo-1-pyrrolidinyl 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB68054843
Molecular Formula: C28H33N3O13
Formula Weight: 619.57
MOL File: 2411681-88-2.mol

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Thalidomide-O-PEG4-NHS ester Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C, sealed storage, away from moisture
solubility: Soluble in DCM
form: Oil
pka: 10.70±0.40(Predicted)
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24453
Product name: Thalidomide-O-PEG4-NHSester
Purity: 98%
Packaging: 100mg
Price: $560
Updated: 2021/12/16

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Thalidomide-O-PEG4-NHS ester Chemical Properties,Usage,Production

Description

Thalidomide-O-PEG4-NHS ester is a synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology it is reactive with amine moiety.

Uses

Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-PEG4-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-PEG4-NHS ester Suppliers

China 18 United States 2 Global 20

Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Xi'an Confluore Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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View Lastest Price from Thalidomide-O-PEG4-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-PEG4-NHS ester 2411681-88-2
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-04-01

2411681-88-2, Thalidomide-O-PEG4-NHS esterRelated Search:

Thalidomide-4-O-C8-NH2 Thalidomide-O-PEG4-Boc 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-amine 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Thalidomide-O-PEG3-amine HCl Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-azide

Thalidomide-O-PEG4-NHS ester

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate

Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

2,5-dioxopyrrolidin-1-yl 1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}-3,6,9,12-tetraoxapentadecan-15-oate

2,5-Dioxopyrrolidin-1-yl 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxapentadecan-15-oate

2,5-Dioxo-1-pyrrolidinyl 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

2411681-88-2