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Thalidomide-O-PEG3-amine HCl

Product Name
Thalidomide-O-PEG3-amine HCl
CAS No.
2387510-82-7
Chemical Name
Thalidomide-O-PEG3-amine HCl
Synonyms
4-(H2N-PEG4)-Thalidomide HCl;Thalidomide-O-PEG3-amine HCl;Thalidomide-PEG4-NH2, HCl salt;Thalidomide 4'-ether-PEG3-amine;Thalidomide-PEG4-NH2 (hydrochloride);Thalidomide-O-PEG3-amine hydrochloride;4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;1H-Isoindole-1,3(2H)-dione, 4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CBNumber
CB29023930
Formula Weight
485.92
MOL File
2387510-82-7.mol
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Thalidomide-O-PEG3-amine HCl Property

form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-PEG3-amine HCl Chemical Properties,Usage,Production

Uses

Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Thalidomide 4'-ether-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11

IC 50

Cereblon

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Thalidomide-O-PEG3-amine HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-PEG3-amine HCl Suppliers

China 12 United States 1 Global 13
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
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View Lastest Price from Thalidomide-O-PEG3-amine HCl manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Thalidomide-O-PEG3-amine hydrochloride 2387510-82-7
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
100mg
Release date
2024-04-01

2387510-82-7, Thalidomide-O-PEG3-amine HClRelated Search:

Thalidomide-4-O-C8-NH2 Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-amine Thalidomide-O-PEG4-NHS ester 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-azide

  • Thalidomide-O-PEG3-amine HCl
  • Thalidomide-PEG4-NH2 (hydrochloride)
  • Thalidomide-O-PEG3-amine hydrochloride
  • 4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
  • Thalidomide-PEG4-NH2, HCl salt
  • 1H-Isoindole-1,3(2H)-dione, 4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
  • Thalidomide 4'-ether-PEG3-amine
  • 4-(H2N-PEG4)-Thalidomide HCl
  • 2387510-82-7