4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid

Product Name: 4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid
CAS No.: 71109-09-6
Chemical Name: 4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid
Synonyms: PM-150;Quadrisol;CERM 10202;Vedaprofen CRS;Vedaprofen Standard;4-Cyclohexyl-α-Methyl-;Vedaprofen, 10 mM in DMSO;Vedaprofen 100 μg/mL in Acetonitrile;2-(4-Cyclohexil-1-naphthyl)-propionic Acid;2-(1-cyclohexylnaphthalen-4-yl)propanoic acid
CBNumber: CB2916590
Molecular Formula: C19H22O2
Formula Weight: 282.38
MOL File: 71109-09-6.mol

More

Less

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Property

Melting point:: 150°C
Boiling point:: 465.9±14.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form: Solid
pka: 4.90±0.30(Predicted)
color: White to off-white
BRN: 5568831
EPA Substance Registry System: 1-Naphthaleneacetic acid, 4-cyclohexyl-.alpha.-methyl- (71109-09-6)

More

Less

Safety

WGK Germany: 3
Toxicity: LD50 orally in rat: 400 mg/kg (Godfroid)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1721
Product name: Vedaprofen
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $152
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001093
Product name: Vedaprofen
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 5 mg
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1721
Product name: Vedaprofen
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $610
Updated: 2025/07/31

Sigma-Aldrich

Product number: 32533
Product name: Vedaprofen
Purity: VETRANAL
Packaging: 10mg
Price: $259
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001093
Product name: Vedaprofen
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001093
Price: $150
Updated: 2024/03/01

More

Less

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Propionic acid type non-steroidal anti-inflammatory drug (NSAID).

Definition

ChEBI: A racemate composed of equal amounts of (R)- and (S)-vedaprofen. Used for control of pain and inflammation particularly associated with chronic musculoskeletal disorders and soft tissue trauma in dogs and horses and for tr atment of pain due to horse colic.

Biological Activity

Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) th at has been found to have antimicrobial activity. Vedaprofen is primarily used as a veterinary analgesic and anti-inflammatory for arthritis and pain. Its anti-inflammatory activity is due to cyclooxygenase inihbition, while its antimicrobial activity is less certain. Vedaprofen can kill B. subtilis by permeabilizing its membrane. Other studies have shown vedaprofen can target the Escherichia coli DNA polymerase III β subunit.

in vivo

Pharmacokinetic parameters of vedaprofen in dogs^[3].

Intravenous dose (mg/kg)	t_1/2β (h)	AUC_{0–48 h} (h·ng/mL)	AUC_0–∞ (h·ng/mL)
0.5	16.8±2.2	8612±1135	9518±1223

Oral dose (mg/kg) t_1/2β (h) C_max (ng/mL) t_max (h) AUC_{0–48 h} (h·ng/mL) AUC_0–∞ (h·ng/mL) F_0–∞ (%)
0.5 12.7±2.1 2739±277 0.63±0.14 7090±1311 7650±1348 86±7

IC 50

COX-1

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Suppliers

Canada 1 China 38 Germany 1 India 1 United Kingdom 1 United States 4 Global 46

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

71109-09-6, 4-cyclohexyl-alpha-methylnaphthalene-1-acetic acidRelated Search:

4-cyclohexylphenylacetic acid (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID 4-ISOPROPYLPHENYLACETIC ACID (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID NAPHTHYL ACETIC ACID 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE 2-(4-butylphenyl)acetate 2-Naphthaleneethanol 4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid HOMO CUMINIC ALDEHYDE 50 1-Naphthaleneacetic acid 4-Pentylphenyl acetic acid 4-N-BUTYLPHENETHYL ALCOHOL hexaprofen p-isopropylphenethyl alcohol

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid

Quadrisol

2-(4-Cyclohexil-1-naphthyl)-propionic Acid

4-Cyclohexyl-a-methyl-1-naphthaleneacetic Acid

CERM 10202

PM-150

4-Cyclohexyl-α-methyl-1-naphthaleneacetic acid

4-Cyclohexyl-α-Methyl-

2-(1-cyclohexylnaphthalen-4-yl)propanoic acid

Vedaprofen CRS

Vedaprofen Standard

1-Naphthaleneacetic acid, 4-cyclohexyl-α-methyl-

(2RS)-2-(4-Cyclohexyl-1-naphthyl)propanoic acid

Vedaprofen,Inhibitor,nonsteroidal,PM150,PM-150,Escherichia coli,inhibit,CERM-10202,CERM10202,COX,serum TxB2,sliding clamp,anti-inflammatory drug,E. coli,PM 150,COX-1 selective,exudate PGE2,Cyclooxygenase,NSAID

2-(4-Cyclohexylnaphthalen-1-yl)propanoic acid

Vedaprofen, 10 mM in DMSO

Vedaprofen 100 μg/mL in Acetonitrile

71109-09-6

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Oral dose (mg/kg)	t_1/2β (h)	C_max (ng/mL)	t_max (h)	AUC_{0–48 h} (h·ng/mL)	AUC_0–∞ (h·ng/mL)	F_0–∞ (%)
0.5	12.7±2.1	2739±277	0.63±0.14	7090±1311	7650±1348	86±7