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ethaverine

Product Name
ethaverine
CAS No.
486-47-5
Chemical Name
ethaverine
Synonyms
ethaverine;Drotaverine Impurity 6;Drotaverine Impurity 3 (Ethaverine);1-(3,4-diethoxybenzyl)-6,7-diethoxyisoquinoline;1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline;Isoquinoline, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-;1-(3,4-diethoxybenzyl)-6,7-diethoxyisoquinoline hydrochloride
CBNumber
CB2929569
Molecular Formula
C24H29NO4
Formula Weight
395.49
MOL File
486-47-5.mol
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ethaverine Property

Melting point:
99-101°
Boiling point:
519.44°C (rough estimate)
Density 
1.1668 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.41±0.40(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E676700
Product name
Ethaverine
Packaging
10mg
Price
$150
Updated
2021/12/16
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ethaverine Chemical Properties,Usage,Production

Chemical Properties

Crystals.Insoluble in water; very soluble in hot alcohol; slightly soluble in ether and chloroform.

Originator

Ethaverine,Shanghai Lansheng

Uses

Ethaverine is an analogue of Papaverine (P190500), an antispasmodic. An isoquinoline derivative with the potential for antimicrobial, antimalarial and cytotoxic antiviral agents.

Definition

ChEBI: 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline is a member of isoquinolines.

Manufacturing Process

(1) 1 part of 2-(3,4-diethoxy-phenyl)-N-[2-(3,4-diethoxy-phenyl)-2-hydroxyethyl]acetamide (homoveratroyl hydroxyhomo-veratrylamine), prepared from 2-amino-1-(3,4-diethoxy-phenyl)ethanol and (3,4-diethoxy-phenyl)acetyl chloride, is dissolved in a neutral solvent, such as, for example, chloroform or benzene. Thereupon, 1 to 3 parts of phosphorus oxychloride are added to the resulting solution and the no whole is heated for some hours under a reflux condenser. It should be pointed out here that it is also possible to occur by allowing the amide solution to flow on to the phosphorus oxychloride with the application of heat or in the cold. Instead of this, it is also possible to carry out the reaction in such a way that the reaction mixture is first allowed to stand in the cold. Then it completed by heating. The base produced in both cases is obtained by shaking with chloroform after distilling off the solvent and after alkalization. MP: 145°-147°C.
(2) 1 part of 2-(3,4-dimethoxyphenyl)ethylamine is dissolved in 2 parts of benzene, 1 to 2 parts of phosphorus pentachloride are added thereto and the whole is heated to boiling. After heating for several hours, the base, which is formed can be isolated as above described. MP: 147°C.
(3) 1 part of N-(3,4-diethoxyphenylacetyl)-β-oxy-β-(3,4- diethoxyphenyl)ethylamine is dissolved in benzene or chloroform, mixed with 1 to 3 parts by weight of phosphorus oxychloride and boiled under a reflux condenser for 3 hours whereupon 6,7-diethoxy-1-(3',4'- diethoxybenzyl)isoquinoline base can be isolated in the usual way. MP: 99°- 101°C.

Therapeutic Function

Spasmolytic, Vasodilator, Antiarrhythmic

ethaverine Preparation Products And Raw materials

Raw materials

Preparation Products

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ethaverine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-52878169 15701683040
Email
sales@bjcomparison.com
Country
China
ProdList
4692
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55896
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
2881290884@qq.com
Country
China
ProdList
7494
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
Tianjin Zhangxin Pharmaceutical Technology Co., Ltd
Tel
022-28219283 18522293726
Email
linda_zxyy@163.com
Country
China
ProdList
41
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
13670046396
Email
ORDERS@QCSRM.COM
Country
China
ProdList
18820
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
10010
Advantage
58

486-47-5, ethaverineRelated Search:


  • ethaverine
  • 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline
  • Isoquinoline, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-
  • 1-(3,4-diethoxybenzyl)-6,7-diethoxyisoquinoline hydrochloride
  • Drotaverine Impurity 6
  • Drotaverine Impurity 3 (Ethaverine)
  • 1-(3,4-diethoxybenzyl)-6,7-diethoxyisoquinoline
  • 486-47-5
  • 985-11-7
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals