ChemicalBook > CAS DataBase List > ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

Product Name
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
CAS No.
53786-45-1
Chemical Name
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
Synonyms
Einecs 258-775-8;Domperidone Impurity 8;Domperidone Impurity 2;Domperidone Impurity 28;ethyl 4-((2-amino-4-chlorophenyl);ETHYL 4-(2-AMINO-4-CHLOROANILINO)PIPERIDINE-1-CARBOXYLATE;ETHYL 4-(2-AMINO-4-CHLOROANILINO)-1-PIPERIDINECARBOXYLATE;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxyl...;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate;4-[(2-Amino-4-chlorophenyl)amino]-1-piperidinecarboxylic acid ethyl ester
CBNumber
CB2930448
Molecular Formula
C14H20ClN3O2
Formula Weight
297.78
MOL File
53786-45-1.mol
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ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Property

Boiling point:
475.6±45.0 °C(Predicted)
Density 
1.290±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.70±0.11(Predicted)
InChI
InChI=1S/C14H20ClN3O2/c1-2-20-14(19)18-7-5-11(6-8-18)17-13-4-3-10(15)9-12(13)16/h3-4,9,11,17H,2,5-8,16H2,1H3
InChIKey
PPCPQDDCMQRJLS-UHFFFAOYSA-N
SMILES
N1(C(OCC)=O)CCC(NC2=CC=C(Cl)C=C2N)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
126682
Product name
Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
Purity
>95%
Packaging
1g
Price
$432
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0323928
Product name
ETHYL 4-[(2-AMINO-4-CHLOROPHENYL)AMINO]PIPERIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$503.61
Updated
2021/12/16
AK Scientific
Product number
Z4845
Product name
Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
Packaging
1g
Price
$292
Updated
2021/12/16
Matrix Scientific
Product number
126682
Product name
Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
Purity
>95%
Packaging
5g
Price
$1296
Updated
2021/12/16
Ambeed
Product number
A303768
Product name
Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
Purity
98%
Packaging
10g
Price
$316
Updated
2021/12/16
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ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 4-((2-Amino-4-chlorophenyl)amino)piperidine-1-carboxylate is an impurity of Domperidone(D531100); a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Synthesis

53786-44-0

53786-45-1

2. 1.34 kg of the crude product (domperidone impurity 7) obtained in the first step was dissolved in a solvent mixture of 15 L of methanol and 15 L of tetrahydrofuran with 1.3 L of water. Subsequently, zinc powder and 1.1 kg of ammonium chloride were added and the reaction was carried out at 25 °C for 5 hours. After completion of the reaction, the zinc powder was removed by filtration. Methanol and tetrahydrofuran were recovered by concentration under reduced pressure. The residue was dissolved in 15 L of ethyl acetate and the organic phase was washed with 15 L of water. The organic phase was recrystallized by adding 1 kg of ethyl acetate and 3 kg of petroleum ether to give 1.06 kg of an off-white solid, domperidone intermediate (DP-2), with 99% purity and 88% yield.

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 5, p. 814 - 820
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 19, p. 5052 - 5056
[3] Patent: US4470989, 1984, A
[4] Patent: CN108358832, 2018, A. Location in patent: Paragraph 0007; 0020; 0023; 0029; 0033; 0037

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl 4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate 53786-45-1
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate 53786-45-1
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

53786-45-1, ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylateRelated Search:

ethyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone 1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER 1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one 1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one Domperidone Impurity 15 DoMperidone-d6 DoMperidone EP IMpurity B TERT-BUTYL 4-[4-(AMINOMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE 4-((4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl)benzonitrile Oxazole, 4-[4-(trifluoromethyl)phenyl]- 4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZONITRILE 4-[[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]OXY]BENZOIC ACID 1-(2-PROPENYL)-2-BENZIMIDAZOLIDINONE DoMperidone EP IMpurity D 2H-Benzimidazol-2-one, 1,1'-(1,3-propanediyl)bis[1,3-dihydro-

  • Domperidone Impurity 2
  • ethyl 4-((2-amino-4-chlorophenyl)
  • ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
  • ETHYL 4-(2-AMINO-4-CHLOROANILINO)PIPERIDINE-1-CARBOXYLATE
  • 4-[(2-Amino-4-chlorophenyl)amino]-1-piperidinecarboxylic acid ethyl ester
  • Einecs 258-775-8
  • 1-PIPERIDINECARBOXYLIC ACID,4-[(2-AMINO-4-CHLOROPHENYL)AMINO]-,ETHYL ESTER
  • Domperidone Impurity 8
  • ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxyl...
  • Domperidone Impurity 28
  • ETHYL 4-(2-AMINO-4-CHLOROANILINO)-1-PIPERIDINECARBOXYLATE
  • 53786-45-1