ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

Product Name: ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
CAS No.: 53786-45-1
Chemical Name: ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
Synonyms: Einecs 258-775-8;Domperidone Impurity 8;Domperidone Impurity 2;Domperidone Impurity 28;ethyl 4-((2-amino-4-chlorophenyl);ETHYL 4-(2-AMINO-4-CHLOROANILINO)PIPERIDINE-1-CARBOXYLATE;ETHYL 4-(2-AMINO-4-CHLOROANILINO)-1-PIPERIDINECARBOXYLATE;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxyl...;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate;4-[(2-Amino-4-chlorophenyl)amino]-1-piperidinecarboxylic acid ethyl ester
CBNumber: CB2930448
Molecular Formula: C14H20ClN3O2
Formula Weight: 297.78
MOL File: 53786-45-1.mol

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ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Property

Boiling point:: 475.6±45.0 °C(Predicted)
Density: 1.290±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.70±0.11(Predicted)
InChI: InChI=1S/C14H20ClN3O2/c1-2-20-14(19)18-7-5-11(6-8-18)17-13-4-3-10(15)9-12(13)16/h3-4,9,11,17H,2,5-8,16H2,1H3
InChIKey: PPCPQDDCMQRJLS-UHFFFAOYSA-N
SMILES: N1(C(OCC)=O)CCC(NC2=CC=C(Cl)C=C2N)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 126682
Product name: Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $432
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0323928
Product name: ETHYL 4-[(2-AMINO-4-CHLOROPHENYL)AMINO]PIPERIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $503.61
Updated: 2021/12/16

AK Scientific

Product number: Z4845
Product name: Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
Packaging: 1g
Price: $292
Updated: 2021/12/16

Matrix Scientific

Product number: 126682
Product name: Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
Purity: >95%
Packaging: 5g
Price: $1296
Updated: 2021/12/16

Ambeed

Product number: A303768
Product name: Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
Purity: 98%
Packaging: 10g
Price: $316
Updated: 2021/12/16

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ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 4-((2-Amino-4-chlorophenyl)amino)piperidine-1-carboxylate is an impurity of Domperidone(D531100); a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Synthesis

53786-44-0

53786-45-1

2. 1.34 kg of the crude product (domperidone impurity 7) obtained in the first step was dissolved in a solvent mixture of 15 L of methanol and 15 L of tetrahydrofuran with 1.3 L of water. Subsequently, zinc powder and 1.1 kg of ammonium chloride were added and the reaction was carried out at 25 °C for 5 hours. After completion of the reaction, the zinc powder was removed by filtration. Methanol and tetrahydrofuran were recovered by concentration under reduced pressure. The residue was dissolved in 15 L of ethyl acetate and the organic phase was washed with 15 L of water. The organic phase was recrystallized by adding 1 kg of ethyl acetate and 3 kg of petroleum ether to give 1.06 kg of an off-white solid, domperidone intermediate (DP-2), with 99% purity and 88% yield.

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 5, p. 814 - 820
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 19, p. 5052 - 5056
[3] Patent: US4470989, 1984, A
[4] Patent: CN108358832, 2018, A. Location in patent: Paragraph 0007; 0020; 0023; 0029; 0033; 0037

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Suppliers

China 46 India 2 Ukraine 1 United Kingdom 1 United States 6 Global 56

Shaanxi Dideu Medichem Co. Ltd

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shanghai Rainbow MediTech.Co.Ltd.

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AN PharmaTech Co Ltd

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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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View Lastest Price from ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate 53786-45-1
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate 53786-45-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

53786-45-1, ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylateRelated Search:

ethyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone 1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER 1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one 1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one Domperidone Impurity 15 DoMperidone-d6 DoMperidone EP IMpurity B TERT-BUTYL 4-[4-(AMINOMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE 4-((4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl)benzonitrile Oxazole, 4-[4-(trifluoromethyl)phenyl]- 4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZONITRILE 4-[[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]OXY]BENZOIC ACID 1-(2-PROPENYL)-2-BENZIMIDAZOLIDINONE DoMperidone EP IMpurity D 2H-Benzimidazol-2-one, 1,1'-(1,3-propanediyl)bis[1,3-dihydro-

Domperidone Impurity 2

ethyl 4-((2-amino-4-chlorophenyl)

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

ETHYL 4-(2-AMINO-4-CHLOROANILINO)PIPERIDINE-1-CARBOXYLATE

4-[(2-Amino-4-chlorophenyl)amino]-1-piperidinecarboxylic acid ethyl ester

Einecs 258-775-8

1-PIPERIDINECARBOXYLIC ACID,4-[(2-AMINO-4-CHLOROPHENYL)AMINO]-,ETHYL ESTER

Domperidone Impurity 8

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxyl...

Domperidone Impurity 28

ETHYL 4-(2-AMINO-4-CHLOROANILINO)-1-PIPERIDINECARBOXYLATE

53786-45-1