4-Chloro-7-hydroxyquinoline
- Product Name
- 4-Chloro-7-hydroxyquinoline
- CAS No.
- 181950-57-2
- Chemical Name
- 4-Chloro-7-hydroxyquinoline
- Synonyms
- 4-chloroquinolin-7-ol;7-Quinolinol, 4-chloro-;4-chloro-1H-quinolin-7-one;4-Chloro-7-hydroxyquinoline
- CBNumber
- CB2947990
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 181950-57-2.mol
4-Chloro-7-hydroxyquinoline Property
- Boiling point:
- 329.3±22.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.41±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C588093
- Product name
- 4-Chloro-7-hydroxyquinoline
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 119339
- Product name
- 4-Chloro-7-hydroxyquinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- OR932346
- Product name
- 4-Chloro-7-hydroxyquinoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- 119339
- Product name
- 4-Chloro-7-hydroxyquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- OR932346
- Product name
- 4-Chloro-7-hydroxyquinoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $696
- Updated
- 2021/12/16
4-Chloro-7-hydroxyquinoline Chemical Properties,Usage,Production
Uses
4-Chloro-7-hydroxyquinoline is a reagent used in the synthesis of novel benzo[d]?oxazol-?2(3H)?-?one derivatives which can act as c-Met kinase inhibitors.
Synthesis
68500-37-8
181950-57-2
General procedure for the synthesis of 4-chloro-7-hydroxyquinoline using 4-chloro-7-methoxyquinoline as starting material: 4-chloro-7-methoxyquinoline (3.86 g, 20 mmol), 40% hydrobromic acid (30 mL) and acetic anhydride (20 mL) were mixed and heated to reflux, and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, 100 mL of water was added to the reaction mixture and the pH was adjusted to 6.0 with 20% sodium hydroxide solution, at which point a large amount of solid precipitated. After filtration, washing and drying, an off-white solid product (3.53 g, 98.6% yield) was obtained.
References
[1] Patent: CN105037266, 2017, B. Location in patent: Paragraph 0323-0326
[2] Patent: CN105017145, 2017, B. Location in patent: Paragraph 0327; 0328; 0329
[3] Patent: CN106749231, 2017, A. Location in patent: Paragraph 0116; 0117; 0118; 0119
[4] European Journal of Medicinal Chemistry, 2019, p. 666 - 678
4-Chloro-7-hydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-7-hydroxyquinoline manufacturers
- Product
- 4-Chloro-7-hydroxyquinoline 181950-57-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08