ChemicalBook > CAS DataBase List > 4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline

Product Name
4-chloro-6,7-dimethoxyquinoline
CAS No.
35654-56-9
Chemical Name
4-chloro-6,7-dimethoxyquinoline
Synonyms
4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-Chloro-6,7-dimethoxy-quinolin;Quinoline, 4-chloro-6,7-dimethoxy-
CBNumber
CB8725015
Molecular Formula
C11H10ClNO2
Formula Weight
223.66
MOL File
35654-56-9.mol
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4-chloro-6,7-dimethoxyquinoline Property

Melting point:
132.0 to 136.0 °C
Boiling point:
325.2±37.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.95±0.30(Predicted)
color 
Pale Brown to Light Brown
InChI
InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey
WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES
N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference
35654-56-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS007782
Product name
4-chloro-6,7-dimethoxyquinoline
Purity
AldrichCPR
Packaging
250mg
Price
$104
Updated
2024/03/01
TCI Chemical
Product number
C2938
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
>98.0%(GC)
Packaging
5g
Price
$94
Updated
2024/03/01
TCI Chemical
Product number
C2938
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
>98.0%(GC)
Packaging
25g
Price
$376
Updated
2024/03/01
TRC
Product number
C365930
Product name
4-Chloro-6,7-dimethoxyquinoline
Packaging
1g
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-D1175
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
99.65%
Packaging
100g
Price
$228
Updated
2021/12/16
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4-chloro-6,7-dimethoxyquinoline Chemical Properties,Usage,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.

4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-6,7-dimethoxyquinoline Suppliers

Shandong Xuande Pharmaceutical Technology Co. LTD
Tel
18866895588
Fax
0531-82777287
Email
dingjiaying@shiningpharm.com
Country
China
ProdList
95
Advantage
55
Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd.
Tel
18001856580
Fax
QQ:2415195517
Email
2415195517@qq.com
Country
China
ProdList
44
Advantage
58
Ningbo jinuo chemical co., LTD
Tel
0574-87314919 057487319282
Email
info@nbinno.com
Country
China
ProdList
7027
Advantage
58
shanghai huiyu
Tel
15380804498
Email
330062898@qq.com
Country
China
ProdList
198
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
ProdList
112
Advantage
61
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers

Nanjing Fred Technology Co., Ltd
Product
6,7-dimethoxy-4-chloroquinoline 35654-56-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Wuhan Boyuan Import & Export Co., LTD
Product
4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000tons
Release date
2023-05-24
Henan Fengda Chemical Co., Ltd
Product
4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30

35654-56-9, 4-chloro-6,7-dimethoxyquinolineRelated Search:


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