4-chloro-6,7-dimethoxyquinoline

Product Name: 4-chloro-6,7-dimethoxyquinoline
CAS No.: 35654-56-9
Chemical Name: 4-chloro-6,7-dimethoxyquinoline
Synonyms: 4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;Quinoline, 4-chloro-6,7-dimethoxy-;4-Chloro-6,7-dimethoxyquinoline >
CBNumber: CB8725015
Molecular Formula: C11H10ClNO2
Formula Weight: 223.66
MOL File: 35654-56-9.mol

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4-chloro-6,7-dimethoxyquinoline Property

Melting point:: 132.0 to 136.0 °C
Boiling point:: 325.2±37.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.95±0.30(Predicted)
color: Pale Brown to Light Brown
InChI: InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey: WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES: N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference: 35654-56-9(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45-24/25
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS007782
Product name: 4-chloro-6,7-dimethoxyquinoline
Purity: AldrichCPR
Packaging: 250mg
Price: $104
Updated: 2024/03/01

TCI Chemical

Product number: C2938
Product name: 4-Chloro-6,7-dimethoxyquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $94
Updated: 2024/03/01

TCI Chemical

Product number: C2938
Product name: 4-Chloro-6,7-dimethoxyquinoline
Purity: >98.0%(GC)
Packaging: 25g
Price: $376
Updated: 2024/03/01

TRC

Product number: C365930
Product name: 4-Chloro-6,7-dimethoxyquinoline
Packaging: 1g
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-D1175
Product name: 4-Chloro-6,7-dimethoxyquinoline
Purity: 99.65%
Packaging: 100g
Price: $228
Updated: 2021/12/16

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4-chloro-6,7-dimethoxyquinoline Chemical Properties,Usage,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.

4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-6,7-dimethoxyquinoline Suppliers

Americas 1 China 322 Europe 2 Germany 1 India 18 Japan 1 Switzerland 1 United Kingdom 8 United States 29 Global 383

Nanjing FuRuisi Medical Technology Co., Ltd.

Tel: 025-83221260
Fax: 02583221260
Email: renqing401@163.com
Country: China
ProdList: 225
Advantage: 55

Shandong Xuande Pharmaceutical Technology Co. LTD

Tel: 18866895588
Fax: 0531-82777287
Email: dingjiaying@shiningpharm.com
Country: China
ProdList: 111
Advantage: 55

Shanghai Huanfu Industrial Co., Ltd.

Tel: 18001856580
Fax: QQ：2415195517
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Country: China
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Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

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Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 886
Advantage: 58

Ningbo jinuo chemical co., LTD

Tel: 0574-87314919 057487319282
Email: info@nbinno.com
Country: China
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shanghai huiyu

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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Fax: 86-22-60979672
Email: marketing@pharmacn.com
Country: China
ProdList: 112
Advantage: 61

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
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Country: China
ProdList: 2210
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Country: China
ProdList: 96815
Advantage: 76

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 822
Advantage: 65

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View Lastest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Wuhan Boyuan Import & Export Co., LTD

Product: 4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-05-24

Nanjing Fred Technology Co., Ltd

Product: 6,7-dimethoxy-4-chloroquinoline 35654-56-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

35654-56-9, 4-chloro-6,7-dimethoxyquinolineRelated Search:

Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]- Cabozantinib impurity 1DYH 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib Malate Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Cabozantinib impurity DX2 Cabozantinib Impurity EXA N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide Cabozantinib Impurity 5 4-Aminoveratrole 4-Amino-2-Chloro-6,7-Dimethoxyquinoline 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ethyl 4-chloro-5,8-dimethoxyquinoline-3-carboxylate 4-CHLORO-7,8-DIMETHOXYQUINOLINE

6,7-DIMETHOXY-4-CHLOROQUINOLINE

4-CHLORO-6,7-DIMETHOXYQUINOLINE

4-Chloro-6,7-dimethoxyquioline

Quinoline, 4-chloro-6,7-dimethoxy-

4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9)

Cabozantinib 4-Chloroquinoline Impurity

4-Chloro-6,7-dimethoxyquinoline &gt

oro-6,7-dimethoxyquinoL

Cabozantinib Impurity 71

4-CHLORO-6,7-DIMETHOXYQUINOLINE ISO 9001：2015 REACH

4-CHLORO-6

7-DIMETHOXYQUINOLINE

Cabozantinib Chloro Analog

35654-56-9

Quinoline&Isoquinoline

35654-56-9