ChemicalBook > CAS DataBase List > 4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline

Product Name
4-chloro-6,7-dimethoxyquinoline
CAS No.
35654-56-9
Chemical Name
4-chloro-6,7-dimethoxyquinoline
Synonyms
4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-Chloro-6,7-dimethoxy-quinolin;Quinoline, 4-chloro-6,7-dimethoxy-
CBNumber
CB8725015
Molecular Formula
C11H10ClNO2
Formula Weight
223.66
MOL File
35654-56-9.mol
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4-chloro-6,7-dimethoxyquinoline Property

Melting point:
132.0 to 136.0 °C
Boiling point:
325.2±37.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.95±0.30(Predicted)
color 
Pale Brown to Light Brown
InChI
InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey
WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES
N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference
35654-56-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS007782
Product name
4-chloro-6,7-dimethoxyquinoline
Purity
AldrichCPR
Packaging
250mg
Price
$104
Updated
2024/03/01
TCI Chemical
Product number
C2938
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
>98.0%(GC)
Packaging
5g
Price
$94
Updated
2024/03/01
TCI Chemical
Product number
C2938
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
>98.0%(GC)
Packaging
25g
Price
$376
Updated
2024/03/01
TRC
Product number
C365930
Product name
4-Chloro-6,7-dimethoxyquinoline
Packaging
1g
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-D1175
Product name
4-Chloro-6,7-dimethoxyquinoline
Purity
99.65%
Packaging
100g
Price
$228
Updated
2021/12/16
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4-chloro-6,7-dimethoxyquinoline Chemical Properties,Usage,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.

4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-6,7-dimethoxyquinoline Suppliers

Americas 1 China 331 Europe 2 Germany 1 India 19 Japan 1 Switzerland 1 United Kingdom 8 United States 30 Global 394
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers

Nanjing Fred Technology Co., Ltd
Product
6,7-dimethoxy-4-chloroquinoline 35654-56-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Wuhan Boyuan Import & Export Co., LTD
Product
4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000tons
Release date
2023-05-24
Henan Fengda Chemical Co., Ltd
Product
4-Chloro-6,7-dimethoxyquinoline 35654-56-9
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30

35654-56-9, 4-chloro-6,7-dimethoxyquinolineRelated Search:

Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]- Cabozantinib impurity 1DYH 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib Malate Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Cabozantinib impurity DX2 Cabozantinib Impurity EXA N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide Cabozantinib Impurity 5 4-Aminoveratrole 4-Amino-2-Chloro-6,7-Dimethoxyquinoline 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ethyl 4-chloro-5,8-dimethoxyquinoline-3-carboxylate 4-CHLORO-7,8-DIMETHOXYQUINOLINE

  • 6,7-DIMETHOXY-4-CHLOROQUINOLINE
  • 4-CHLORO-6,7-DIMETHOXYQUINOLINE
  • 4-Chloro-6,7-dimethoxyquioline
  • Quinoline, 4-chloro-6,7-dimethoxy-
  • 4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9)
  • Cabozantinib 4-Chloroquinoline Impurity
  • 4-Chloro-6,7-dimethoxyquinoline &gt
  • oro-6,7-dimethoxyquinoL
  • Cabozantinib Impurity 71
  • 4-CHLORO-6,7-DIMETHOXYQUINOLINE ISO 9001：2015 REACH
  • 4-CHLORO-6
  • 7-DIMETHOXYQUINOLINE
  • Cabozantinib Chloro Analog
  • 4-Chloro-6,7-dimethoxy-quinolin
  • 4-Chloro-6,7-dimethoxyquinoline carboxylic Acid
  • 35654-56-9
  • Quinoline&Isoquinoline
  • 35654-56-9