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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Product Name
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
CAS No.
849217-48-7
Chemical Name
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
Synonyms
1-((4-FL;Cabozantinib impurities4;Cabozantinib Impurity 83;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;1-((4-Fluorophenyl)carbamoyl);FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid
CBNumber
CB52460100
Molecular Formula
C11H10FNO3
Formula Weight
223.2
MOL File
849217-48-7.mol
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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Property

Melting point:
173.0 to 177.0 °C
Boiling point:
475.2±30.0 °C(Predicted)
Density 
1.521
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.48±0.20(Predicted)
color 
White to Almost white
InChI
InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
InChIKey
PFMAFXYUHZDKPY-UHFFFAOYSA-N
SMILES
C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1
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Safety

HS Code 
2924.29.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1083
Product name
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
F1083
Product name
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$318
Updated
2024/03/01
TRC
Product number
F632340
Product name
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W8765
Product name
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging
1g
Price
$27
Updated
2021/12/16
AK Scientific
Product number
W8765
Product name
1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging
25g
Price
$321
Updated
2021/12/16
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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White powdery substance.

Uses

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

Synthesis

Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Suppliers

Americas 1 China 239 Europe 1 India 11 Japan 1 United States 8 Global 261
Beijing Bewellunion Pharmaceutical Co., Ltd.
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Shandong Xuande Pharmaceutical Technology Co. LTD
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Energy Chemical
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View Lastest Price from 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid 849217-48-7
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Longbang Technology Co., Ltd
Product
CYCLOPROPANECARBOXYLIC ACID 849217-48-7
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-04-28
Hebei Zhuanglai Chemical Trading Co Ltd
Product
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid 849217-48-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-24

849217-48-7, 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acidRelated Search:

2-Aminocyclohexanone 4-Aminodiphenylamine 4-Benzothiazolamine (9CI) 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Malate 4-Aminoveratrole Cabozantinib Impurity 5 N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide 4-chloro-6,7-dimethoxyquinoline Cabozantinib Impurity EXA Cabozantinib impurity DX2 Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]- 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib impurity 1DYH Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-

  • 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
  • Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]-
  • 1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid
  • InterMediate of Cabozantinib
  • FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
  • ((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid
  • 1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
  • 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)
  • Intermediate2 of Cabozantinib
  • 1-((4-FL
  • 1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid
  • Cabozantinib impurities4
  • 1-((4-Fluorophenyl)carbamoyl)
  • Cabozantinib Impurity 83
  • 849217-48-7
  • 849214-48-7
  • 849217-48-7