1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Product Name: 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
CAS No.: 849217-48-7
Chemical Name: 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
Synonyms: 1-((4-FL;Cabozantinib impurities4;Cabozantinib Impurity 83;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;1-((4-Fluorophenyl)carbamoyl);FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid
CBNumber: CB52460100
Molecular Formula: C11H10FNO3
Formula Weight: 223.2
MOL File: 849217-48-7.mol

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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Property

Melting point:: 173.0 to 177.0 °C
Boiling point:: 475.2±30.0 °C(Predicted)
Density: 1.521
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 3.48±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
InChIKey: PFMAFXYUHZDKPY-UHFFFAOYSA-N
SMILES: C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1

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Safety

HS Code: 2924.29.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1083
Product name: 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: F1083
Product name: 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $286
Updated: 2025/07/31

TRC

Product number: F632340
Product name: 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W8765
Product name: 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging: 1g
Price: $27
Updated: 2021/12/16

AK Scientific

Product number: W8765
Product name: 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
Packaging: 5g
Price: $101
Updated: 2021/12/16

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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White powdery substance.

Uses

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

Synthesis

Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).

References

[1] Patent: CN104817497, 2017, B. Location in patent: Paragraph 0120; 0121; 0122
[2] Patent: WO2013/59788, 2013, A1. Location in patent: Paragraph 0055; 0056
[3] Patent: WO2013/70890, 2013, A1. Location in patent: Paragraph 00114-00116
[4] Patent: WO2014/165786, 2014, A1. Location in patent: Paragraph 00192-00193
[5] Patent: WO2014/165779, 2014, A1. Location in patent: Paragraph 0075; 0076; 0077; 0078

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Suppliers

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View Lastest Price from 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid 849217-48-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 2000KGS
Release date: 2025-10-24

HebeiShuoshengImportandExportco.,Ltd

Product: 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid 849217-48-7
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-09

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid 849217-48-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-24

849217-48-7, 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acidRelated Search:

2-Aminocyclohexanone 4-Aminodiphenylamine 4-Benzothiazolamine (9CI) 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Malate 4-Aminoveratrole Cabozantinib Impurity 5 N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide 4-chloro-6,7-dimethoxyquinoline Cabozantinib Impurity EXA Cabozantinib impurity DX2 Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]- 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib impurity 1DYH Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-

1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID

Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]-

1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid

InterMediate of Cabozantinib

FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID

((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid

1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID

1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)

Intermediate2 of Cabozantinib

1-((4-FL

1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid

Cabozantinib impurities4

1-((4-Fluorophenyl)carbamoyl)

Cabozantinib Impurity 83

849217-48-71-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylicacid

849217-48-7

849214-48-7

849217-48-7