4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Product Name: 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
CAS No.: 190728-25-7
Chemical Name: 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Synonyms: Benzenam;4-(6,7-Dimethoxy-quinoL;Cabozantinib Amine Analog;Intermediate 1 of Cabozantinib;Cabozantinib Genotoxic Impurity I;4-[(6,7-dimethoxy-4-quinolinyl)oxy]-;4-(6,7-dimethoxy quinolinoxy) aniline;4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline;6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
CBNumber: CB52652846
Molecular Formula: C17H16N2O3
Formula Weight: 296.32
MOL File: 190728-25-7.mol

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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Property

Melting point:: 211.0 to 215.0 °C
Boiling point:: 481.8±45.0 °C(Predicted)
Density: 1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
form: powder to crystal
pka: 6.79±0.30(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
InChIKey: VXEQRXJATQUJSN-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1

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Safety

HS Code: 2933.49.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5070
Product name: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging: 200mg
Price: $155
Updated: 2024/03/01

TCI Chemical

Product number: D5070
Product name: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging: 1g
Price: $460
Updated: 2024/03/01

Chem-Impex

Product number: 43936
Product name: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 1G
Price: $540.8
Updated: 2021/12/16

AK Scientific

Product number: J90694
Product name: 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
Packaging: 1g
Price: $20
Updated: 2021/12/16

Ambeed

Product number: A138452
Product name: 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Purity: 97%
Packaging: 5g
Price: $54
Updated: 2021/12/16

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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties,Usage,Production

Uses

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Suppliers

Americas 1 China 170 Europe 1 India 9 Japan 1 United States 10 Global 192

Shanghai Huanfu Industrial Co., Ltd.

Tel: 18001856580
Fax: QQ：2415195517
Email: 2415195517@qq.com
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Advantage: 58

Shandong Xuande Pharmaceutical Technology Co. LTD

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Fax: 0531-82777287
Email: dingjiaying@shiningpharm.com
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shanghai huiyu

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Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60182192,1339732154 18722583064
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ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Wuhan Sunrise Technology Development Co., Ltd.

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Shanghai XueEr Pharmaceutical Technology Co., Ltd

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View Lastest Price from 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Nanjing Fred Technology Co., Ltd

Product: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

LY Global chemicals co.,ltd .

Product: BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 190728-25-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

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