ChemicalBook > CAS DataBase List > 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Product Name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
CAS No.
190728-25-7
Chemical Name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Synonyms
Benzenam;4-(6,7-Dimethoxy-quinoL;Cabozantinib Amine Analog;Intermediate 1 of Cabozantinib;Cabozantinib Genotoxic Impurity I;4-[(6,7-dimethoxy-4-quinolinyl)oxy]-;4-(6,7-dimethoxy quinolinoxy) aniline;4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline;6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
CBNumber
CB52652846
Molecular Formula
C17H16N2O3
Formula Weight
296.32
MOL File
190728-25-7.mol
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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Property

Melting point:
211.0 to 215.0 °C
Boiling point:
481.8±45.0 °C(Predicted)
Density 
1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
powder to crystal
pka
6.79±0.30(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
InChIKey
VXEQRXJATQUJSN-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1
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Safety

HS Code 
2933.49.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5070
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging
200mg
Price
$155
Updated
2024/03/01
TCI Chemical
Product number
D5070
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging
1g
Price
$460
Updated
2024/03/01
Chem-Impex
Product number
43936
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
1G
Price
$540.8
Updated
2021/12/16
AK Scientific
Product number
J90694
Product name
4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
Packaging
1g
Price
$20
Updated
2021/12/16
Ambeed
Product number
A138452
Product name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Purity
97%
Packaging
5g
Price
$54
Updated
2021/12/16
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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties,Usage,Production

Uses

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Suppliers

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View Lastest Price from 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Henan Fengda Chemical Co., Ltd
Product
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
LY Global chemicals co.,ltd .
Product
BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 190728-25-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
100kg
Release date
2023-03-11

190728-25-7, 4-((6,7-Dimethoxyquinolin-4-yl)oxy)anilineRelated Search:

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Cabozantinib Malate

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  • 190728-25-7
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