5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde

Product Name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
CAS No.: 207290-72-0
Chemical Name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
Synonyms: 5-(4-Hydroxypiperidino)-2-Thio;5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde;5-(4-Hydroxypiperidino)-2-thiophenecarboxaldehyde;5-(4-Hydroxypiperidino)thiophene-2-carboxaldehyde;5-(4-hydroxypiperidin-1-yl)thiophene-2-carbaldehyde;5-(4-Hydroxy-1-piperidinyl)-2-thiophenecarboxaldehyde;2-Thiophenecarboxaldehyde, 5-(4-hydroxy-1-piperidinyl)-;2-Formyl-5-(4-hydroxypiperidin-1-yl)thiophene, 1-(5-Formylthien-2-yl)-4-hydroxypiperidine
CBNumber: CB2948018
Molecular Formula: C10H13NO2S
Formula Weight: 211.28
MOL File: 207290-72-0.mol

More

Less

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Property

Melting point:: 137-139°
Boiling point:: 417.8±45.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 14.77±0.20(Predicted)
color: Light yellow to Brown
λmax: 371nm(MeOH)(lit.)

More

Less

Safety

HazardClass: IRRITANT
HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: H1550
Product name: 5-(4-Hydroxypiperidin-1-yl)thiophene-2-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 200mg
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: H1550
Product name: 5-(4-Hydroxypiperidin-1-yl)thiophene-2-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $93
Updated: 2025/07/31

TRC

Product number: H852970
Product name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H852970
Product name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
Packaging: 100mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: V0677
Product name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
Packaging: 25g
Price: $1063
Updated: 2021/12/16

More

Less

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Chemical Properties,Usage,Production

Synthesis

5382-16-1

4701-17-1

207290-72-0

1. 5-bromothiophene-2-carbaldehyde (42.30 g) was placed in a reactor and an appropriate amount of water was added. 2. 4-hydroxypiperidine (67.30 g, 3 eq.) was added to the reactor and the mixture was stirred under reflux conditions for tens of minutes until overnight. 3. Immediately after completion of the reaction, the reaction mixture was filtered through filter paper, and the filtrate was cooled with water for tens of minutes, followed by chilling with ice for several hours. 4. The precipitated crystals are collected by diafiltration and washed with cold water. 5. 5. The crystals are dried and dissolved in chloroform and the chloroform solution is dried with anhydrous sodium sulfate. 6. The dried solution is filtered through a pad of silica gel and washed with chloroform until the filtrate becomes pale in color. 7. Concentrate the filtrate under pressure until it begins to crystallize, add n-hexane and stir overnight at room temperature. 8. The crystals formed were collected by filtration, washed with hexane and dried under reduced pressure to give 5-(4-hydroxypiperidin-1-yl)-thiophene-2-carbaldehyde (33.00 g, 71%). 9. 5-(4-hydroxypiperidin-1-yl)-thiophene-2-carboxaldehyde (10.56 g) was subjected to a condensation reaction with 3,4-dimethoxybenzyl cyanide (8.86 g) to give (Z)-2-(3,4-dimethoxyphenyl)-3-[5-(4-hydroxypiperidin-1-yl)-thiophen-2-yl]-acrylonitrile (13.50 g, 73%). 10. (Z)-2-(3,4-dimethoxyphenyl)-3-[5-(4-hydroxypiperidin-1-yl)-thiophen-2-yl]-acrylonitrile (20.00 g) was dissolved in chloroform (650 mL), and pyridine (6.41 g) and bromoacetyl bromide (14.13 g) were added and reacted to give bromoacetic acid 1-[5-[(Z)-2-cyano-2-(3,4-di (Z)-2-cyano-2-(3,4-dimethoxyphenyl)-vinyl]-thiophen-2-yl]-piperidin-4-yl ester (23.00 g, 87%). 11. 1-[5-[(Z)-2-cyano-2-(3,4-dimethoxyphenyl)-vinyl]-thiophen-2-yl]-piperidin-4-yl ester of bromoacetic acid (2.30 g) was dissolved in chloroform (100 mL), and piperidine (533 mg) and triethylamine (658 mg) were added and reacted to give 5-(4-hydroxypiperidinyl)-2-thiophenecarboxaldehyde (1.40 g. 60%).

References

[1] Synlett, 1998, # 4, p. 383 - 384
[2] Synthetic Communications, 2000, vol. 30, # 8, p. 1359 - 1364
[3] Patent: EP2218719, 2010, A1. Location in patent: Page/Page column 7-8

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Suppliers

Americas 1 CHINA 62 Europe 1 India 3 Japan 1 United Kingdom 3 United States 8 Global 79

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

207290-72-0, 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehydeRelated Search:

Tetrahydrothiophene 2-Thiophenecarboxaldehyde Chrysin Haloperidol Salicylaldehyde 4-Hydroxybenzaldehyde 5-PIPERIDIN-1-YL-THIOPHENE-2-CARBALDEHYDE DIHYDROXY BENZALDEHYDE 1-(THIEN-2-YL)-PIPERIDINE 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde

5-(4-Hydroxypiperidino)-2-Thio

5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde

2-Formyl-5-(4-hydroxypiperidin-1-yl)thiophene, 1-(5-Formylthien-2-yl)-4-hydroxypiperidine

5-(4-hydroxypiperidin-1-yl)thiophene-2-carbaldehyde

5-(4-Hydroxy-1-piperidinyl)-2-thiophenecarboxaldehyde

2-Thiophenecarboxaldehyde, 5-(4-hydroxy-1-piperidinyl)-

5-(4-Hydroxypiperidino)thiophene-2-carboxaldehyde

5-(4-Hydroxypiperidino)-2-thiophenecarboxaldehyde

207290-72-0

Piperidine

Thiophene intermediates