3-Bromo-L-phenylalanine
Uses- Product Name
- 3-Bromo-L-phenylalanine
- CAS No.
- 82311-69-1
- Chemical Name
- 3-Bromo-L-phenylalanine
- Synonyms
- L-3-Br-phe;L-3-BR-PHE-OH;3-Br-L-Phe-OH;L-Phe(3-Br)-OH;RRSYY(Avadomide)-5;(L)-Bromophenyl alanine;m-Bromo-L-phenylalanine;3-Bromo-L-phenylalanine;L-Phenylalanine, 3-bromo-;3-Bromo-L-phenylalanine,95%
- CBNumber
- CB2948139
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 82311-69-1.mol
3-Bromo-L-phenylalanine Property
- Boiling point:
- 368.4±32.0 °C(Predicted)
- Density
- 1.588±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.16±0.10(Predicted)
- form
- solid
- color
- White to off white
- optical activity
- Consistent with structure
- Water Solubility
- Slightly soluble in water.
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B789320
- Product name
- 3-Bromo-L-phenylalanine
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- B789320
- Product name
- 3-Bromo-L-phenylalanine
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 265342
- Product name
- 3-Bromo- L-phenylalanine
- Packaging
- 1g
- Price
- $379
- Updated
- 2021/12/16
- Product number
- AS39494
- Product name
- (S)-2-Amino-3-(3-bromophenyl)propanoic acid
- Purity
- 98% ee
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 14322
- Product name
- 3-Bromo- L-phenylalanine
- Purity
- ≥ 99% (HPLC)
- Packaging
- 250MG
- Price
- $30
- Updated
- 2021/12/16
3-Bromo-L-phenylalanine Chemical Properties,Usage,Production
Uses
3-Bromo-L-phenylalanine is used in preparation of lifitegrast intermediate.
Chemical Properties
White to off-white powder
Uses
It is applied in the facile removal of leader peptides from lanthipeptides by incorporation of a hydroxy acid.
Uses
3-Bromo-L-phenylalanine is used in preparation of lifitegrast intermediate.
Synthesis
82278-73-7
82311-69-1
The general procedure for the synthesis of (S)-2-amino-3-(3-bromophenyl)propionic acid from (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid was as follows: (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid (5.0 g, 14.5 mmol) was suspended in a 1,4-dioxane solution of 4 M hydrochloric acid (75 mL ) and the reaction was stirred at room temperature for 16 hours. Upon completion of the reaction, the white precipitate was collected by filtration and washed with ether (Et2O) to afford (S)-2-amino-3-(3-bromophenyl)propionic acid (3.2 g, 89% yield) as a white solid, and the product did not require further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) data of the product were as follows: δ 8.32 (2H, s), 7.50-7.48 (2H, m), 7.34-7.29 (2H, m), 4.22 (1H, t, J=6.2 Hz), 3.13-3.11 (2H, m).
References
[1] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 42
[2] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 61
3-Bromo-L-phenylalanine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-L-phenylalanine Suppliers
- Tel
- --
- Fax
- --
- sales@chemcube.eu
- Country
- Germany
- ProdList
- 4083
- Advantage
- 34
View Lastest Price from 3-Bromo-L-phenylalanine manufacturers
- Product
- 3-Bromo-L-phenylalanine 82311-69-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 3-Bromo-L-phenylalanine 82311-69-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-30