ChemicalBook > CAS DataBase List > Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Product Name
Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
CAS No.
139481-69-9
Chemical Name
Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
Synonyms
Candesartan Methyl Ester;Candesartan Impurity 7;candesartan methyl ester imp;Candesartan Cilexetil impurity I;Candesartan methyl ester impurity;candesartan cilexetil impurity1361;Candesartan Cilexetil EP IMpurity I;Candesartan EP Impurity-I (methyl ester);CANDESARTAN INTERMEDIATES(METHYL ESTER C7);Candesartan Cilexetil Impurity 9(EP Impurity I)
CBNumber
CB2949303
Molecular Formula
C25H22N6O3
Formula Weight
454.48
MOL File
139481-69-9.mol
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Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Property

Melting point:
169-173°C
Boiling point:
704.5±70.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid:particulate/powder
pka
4.15±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2022
Product name
Candesartan Cilexetil Impurity I
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
20 mg
Price
$411.6
Updated
2025/07/31
Biosynth Carbosynth
Product number
FC19664
Product name
Candesartan methyl ester
Packaging
5mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
6781AA
Product name
Methyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
Packaging
10g
Price
$201
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19664
Product name
Candesartan methyl ester
Packaging
10mg
Price
$272.6
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19664
Product name
Candesartan methyl ester
Packaging
25mg
Price
$496
Updated
2021/12/16
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Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Candesartan Methyl Ester (Candesartan Cilexetil EP Impurity I) is an intermediate in the preparation of Candesartan (C175575).

Synthesis

139481-44-0

139481-69-9

1. Methyl 2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylate (310 g) and toluene (2.48 L) were added to a reactor, followed by tributyltin chloride (737 g), sodium azide (146 g) and tetrabutylammonium bromide (31 g). 2. The reaction mixture was slowly heated to 110 °C and maintained at 110-115 °C for 24 h, during which the progress of the reaction was monitored by TLC. 3. After completion of the reaction, the reaction mixture was cooled to 15 °C and methanol (3.1 L), water (2.17 L) and acetic acid (930 g) were added sequentially. 4. The mixture was stirred at 15-20 °C for 1 h to promote product separation. 5. After addition of toluene (1.24 L), the reaction mixture was filtered at 15-20 °C. 6. the filter cake was washed thoroughly with water (0.93 L) until the pH of the wash solution reached 5.5-7.0 to completely remove the acid. 7. The filter cake was washed again with toluene (0.62 L) and dried by suction filtration. 8. The product was air dried at 50-55 °C to give methyl 2-ethoxy-1-[[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole]-7-carboxylate. Yield: 290 g (85%).

IC 50

AT2 Receptor: 0.11 μM (IC50)

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 15, p. 2182 - 2195
[2] Patent: WO2005/51929, 2005, A1. Location in patent: Page/Page column 18
[3] Patent: US2009/203920, 2009, A1. Location in patent: Page/Page column 4
[4] Patent: EP1420016, 2004, A1. Location in patent: Page 19
[5] Patent: WO2009/157001, 2009, A2. Location in patent: Page/Page column 3

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Suppliers

Canada 1 China 126 India 15 United Kingdom 1 United States 8 Global 151
J & K SCIENTIFIC LTD.
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View Lastest Price from Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 139481-69-9
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 139481-69-9
Price
US $30.00-28.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2022-09-28
Shaanxi Dideu Medichem Co. Ltd
Product
Candesartan Methyl Ester 139481-69-9
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26

139481-69-9, Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-CarboxylateRelated Search:

Candesartan cilexetil Trityl candesartan cilexetil Candesartan Methyl Ester Desethyl Analog N-Trityl Candesartan Ethyl Ester 5-(phenylazo)salicylic acid CV 15959 CANDESARTAN-D5 Candesartan Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid ethyl ester BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER Methyl 2-ethoxybenzimidazole-7-carboxylate Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate CANDESARTAN CILEXETIL-D11 O-Desetheyl Candesartan Ethyl Ester

  • Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-ca
  • methyl 1-((2,-(1H-tetrazol-5-yl)-[1,1,-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
  • Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7
  • Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
  • ETHYL2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)METHYL]BENZIMIDAZOLE-7-CARBOXYLATE
  • thyl-2-ethoxy-1-[[2'-(1Htetrazol-5-yl-)methyl]benzimidazole]-7-carboxylate
  • Candesartan Methyl Ester
  • 2-ethoxy-4-ethyl-1-{[4-phenyl-3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]Methyl}-1H-1,3-benzodiazole-7-carboxylate
  • 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid Methyl Ester
  • Candesartan Cilexetil EP IMpurity I
  • Candesartan Cilexetil impurity I
  • 2-Ethoxy-1-[[2-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
  • Candesartan Impurity 7
  • Candesartan Cilexetil Impurity 9(EP Impurity I)
  • 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methyl ester
  • CANDESARTAN INTERMEDIATES(METHYL ESTER C7)
  • Candesartan Cilexetil EP Impurity I (Candesartan Methyl Ester)
  • Candesartan methyl ester impurity
  • candesartan methyl ester imp
  • Methyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Meth...
  • candesartan cilexetil impurity1361
  • Candesartan Cilexetil EP Impurity IQ: What is Candesartan Cilexetil EP Impurity I Q: What is the CAS Number of Candesartan Cilexetil EP Impurity I Q: What is the storage condition of Candesartan Cilexetil EP Impurity I Q: What are the applications of Candesartan Cilexetil EP Impurity I
  • Candesartan Cilexetil Impurity 9(Candesartan Cilexetil EP Impurity I)
  • Methyl 1-[[2’-(5-Tetrazolyl)-4-biphenylyl]methyl]-2-ethoxybenzimidazole-7-carboxylate
  • Methyl 2-ethoxy-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]benzoimidazole-7-carboxylate
  • Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
  • 2-Ethoxy-1-[[2'-(2H-Tetrazol-5-yl)[1,1'-Biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylicacidMethylEster
  • Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (Candesartan Cilexetil Impurity)
  • Candesartan EP Impurity-I (methyl ester)
  • methyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
  • thyl-2-ethoxy-1-[[2’-(1Htetrazol-5-yl-)methyl]benzimidazole]-7-carboxylate
  • Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (Cande
  • Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
  • Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (Candesartan Methyl Ester)
  • 139481-69-9
  • C25H22N6O3
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