Methyl 2-ethoxybenzimidazole-7-carboxylate
- Product Name
- Methyl 2-ethoxybenzimidazole-7-carboxylate
- CAS No.
- 150058-27-8
- Chemical Name
- Methyl 2-ethoxybenzimidazole-7-carboxylate
- Synonyms
- Azilsartan Impurity 38;Methyl-2-ethoxy-1H-benz;Candesartan intermediate;Candesartan BenziMidazole Ethoxy IMpurity;Methyl 2-ethoxybenzimidazole-7-carboxylate;Methyl 2-ethoxybenzoimidazole-4-carboxylate;Candesartan Benzimidazole Ethoxy Methyl Ester;Methyl 2-ethoxy-3H-benziMidazole-4-carboxylate;methyl 2-ethoxy-1H-benzimidazole-4-carboxylate;Methyl 2-ethoxybenziMidazole-4-carboxylate, 97%
- CBNumber
- CB52490053
- Molecular Formula
- C11H12N2O3
- Formula Weight
- 220.22
- MOL File
- 150058-27-8.mol
Methyl 2-ethoxybenzimidazole-7-carboxylate Property
- Boiling point:
- 373.1±34.0 °C(Predicted)
- Density
- 1.269
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform, Methanol
- form
- Solid
- pka
- 8.99±0.30(Predicted)
- color
- Dark Reddish Orange to Dark Brown
- InChI
- InChI=1S/C11H12N2O3/c1-3-16-11-12-8-6-4-5-7(9(8)13-11)10(14)15-2/h4-6H,3H2,1-2H3,(H,12,13)
- InChIKey
- MOPLKVMMSFGZIR-UHFFFAOYSA-N
- SMILES
- C1(OCC)NC2=C(C(OC)=O)C=CC=C2N=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 011432
- Product name
- 2-Ethoxy-3H-benzimidazole-4-carboxylic Acid Methyl Ester
- Packaging
- 2.5g
- Price
- $418
- Updated
- 2021/12/16
- Product number
- Y7591
- Product name
- Methyl2-ethoxy-3H-benzo[d]imidazole-4-carboxylate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Y7591
- Product name
- Methyl2-ethoxy-3H-benzo[d]imidazole-4-carboxylate
- Packaging
- 1g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- CHM0077811
- Product name
- 2-ETHOXY-3H-BENZIMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $847
- Updated
- 2021/12/16
- Product number
- 57813
- Product name
- 2-Ethoxy-3H-benzimidazole-4-carboxylicAcidMethylEster
- Packaging
- 25g
- Price
- $1460
- Updated
- 2021/12/16
Methyl 2-ethoxybenzimidazole-7-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Dark Reddish Orange Solid
Uses
An intermediate in the preparation of labelled Candesartan.
Synthesis
78-09-1
107582-20-7
150058-27-8
1. Methyl 2-amino-3-nitrobenzoate (150.0 g, 0.765 mol) was placed in an autoclave and ethyl acetate (1000 mL) and nickel ruanne (75 g) were added. The reaction mixture was stirred at 12-15 °C for 20-25 h under hydrogen pressure (2-3 kg/cm2). Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the diatomaceous earth was washed with ethyl acetate (150 mL). The filtrate was distilled under reduced pressure and the solvent was completely removed at 45-50 °C. 2. Acetic acid (171 mL) was added to the residue, and raw tetraethyl carbonate (180 g) was added slowly over 30-45 minutes. The reaction mixture was stirred at 25-35 °C for 2-3 hours. 3. Cool the reaction mixture to 0-5 °C and slowly add water (750 mL) over 15-30 min. The precipitated solid was filtered and washed sequentially with water (150 mL) and ethyl acetate (150 mL). 4. The resulting solid was dried at 55-65 °C for 10-12 h to afford methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (140 g, 83.1% yield).
References
[1] Patent: WO2006/15134, 2006, A1. Location in patent: Page/Page column 15; 16
[2] Patent: CN104876877, 2018, B. Location in patent: Paragraph 0033; 0069-0072
Methyl 2-ethoxybenzimidazole-7-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-ethoxybenzimidazole-7-carboxylate manufacturers
- Product
- Methyl 2-ethoxybenzimidazole-7-carboxylate 150058-27-8
- Price
- US $300.00-260.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
- Product
- Methyl-2-ethoxybenzimidazole-7-carboxylate 150058-27-8
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-10-21
- Product
- Methyl 2-ethoxybenzimidazole-7-carboxylate 150058-27-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-09-07