1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid

Product Name: 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid
CAS No.: 98105-79-4
Chemical Name: 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid
Synonyms: Difloxacin impurity G;Difloxacin EP Impurity G;Difloxacin EP Impurituy G;1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid;7-chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-3-quinolinecarboxylic acid;7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxoquinoline-3-carboxylic acid;1-(4-Fluorophenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylicacid;1-4(4-FLUOROPHENYL)-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3- C ARBOXYLIC;7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;7-CHLORO-6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
CBNumber: CB2971467
Molecular Formula: C16H8ClF2NO3
Formula Weight: 335.69
MOL File: 98105-79-4.mol

More

Less

1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid Property

Melting point:: 260-264℃
Boiling point:: 514℃
Density: 1.584
Flash point:: 265℃
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Major Application: pharmaceutical (small molecule)
InChI: 1S/C16H8ClF2NO3/c17-12-6-14-10(5-13(12)19)15(21)11(16(22)23)7-20(14)9-3-1-8(18)2-4-9/h1-7H,(H,22,23)
InChIKey: FBAMWRYINJFGPJ-UHFFFAOYSA-N
SMILES: Fc1ccc(cc1)[n]2c3c([c](c(c2)C(=O)O)=O)cc(c(c3)Cl)F

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001429
Product name: Difloxacin impurity G
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $127
Updated: 2026/03/19

Sigma-Aldrich

Product number: Y0001429
Product name: Difloxacin impurity G
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001429
Price: $156
Updated: 2024/03/01

TRC

Product number: C366355
Product name: 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcid
Packaging: 25mg
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 093037
Product name: 7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026355
Product name: 7-CHLORO-6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $501.75
Updated: 2021/12/16

More

Less

1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid Chemical Properties,Usage,Production

Uses

7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is a 1-arylated derivative of 1,4-dihydro-4-oxoquinoline-3-carboxylic acid with antibacterial activity.

Synthesis

1-(p-Fluoro-phenyl)-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid was synthesised by a three-step procedure. Step 1: Preparation of 2,4-dichloro-5-fluoroacetophenone. 2,4-Dichlorofluorobenzene undergoes a Friedel-Crafts reaction with AcCl catalyzed by anhydrous AlCl3. Step 2: Preparation of methyl -(2,4-dichloro-5-fluorobenzoyl)--(4-fluoroanilino)acrylate. The ketone from step 1 reacts with (MeO)2CO and NaH, then with a dimethyl sulfate/DMF complex. Water is added, followed by p-fluoroaniline to give the product. Step 3: Preparation of 7-chloro-6-fluoro-1-p-fluorophenyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. The product from step 2 reacts with NaH in chlorobenzene. NaOH solution is then added for hydrolysis. Acidification precipitates the product.

1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid Suppliers

Canada 1 China 41 India 2 Slovakia 1 United Kingdom 1 United States 6 Global 52

Suzhou Uni-Inno Biomedical Co., Ltd

Tel: 13222205691
Email: 279078865@qq.com
Country: China
ProdList: 496
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: sales@uhnshanghai.com
Country: China
ProdList: 1984
Advantage: 58

Shanghai Tube Pharmaceutical Co., Ltd.

Tel: 021-54338626 18017892860
Fax: 021-54338626
Email: sales@tubepharm.com
Country: China
ProdList: 2657
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 021-4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52678
Advantage: 58

More

Less

View Lastest Price from 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid 98105-79-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2024-11-10

98105-79-4, 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acidRelated Search:

CHLOROPHENYLSILANE Sulfenone 2-FLUOROPHENYL CYCLOPENTYL KETONE DIPHENYLENEIODONIUM CHLORIDE Ethanone,1-(2-amino-4-chloro-5-fluorophenyl)- AKOS 1300 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid 4-FLUORODIPHENYLAMINE 3-(4-Chloro-3-fluorophenyl)-2-methylprop-1-ene AKOS 95 3-(4-CHLORO-3-FLUOROPHENYL)-1-PROPENE

1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid

1-4(4-FLUOROPHENYL)-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3- C ARBOXYLIC

1-(4-Fluorophenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylicacid

7-CHLORO-6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Difloxacin impurity G

7-chloro-6-fluoro-1-(4-fluorophenyl)-4-oxo-3-quinolinecarboxylic acid

Difloxacin EP Impurituy G

Difloxacin EP Impurity G

3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-

7-Chloro-6-fluoro-1-(4-fluorophenyl)-4-oxoquinoline-3-carboxylic acid

7-Chloro-6-fluoro-1-(4'-fluoro phenyl)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

98105-79-4

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals