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DIPHENYLENEIODONIUM CHLORIDE

Product Name
DIPHENYLENEIODONIUM CHLORIDE
CAS No.
4673-26-1
Chemical Name
DIPHENYLENEIODONIUM CHLORIDE
Synonyms
DPI;DPI CHLORIDE;ibenziodoliumchloride;DIBENZIODOLIUM CHLORIDE;DIPHENYLENEIODONIUM CHLORIDE;Dibenz[b,d]iodoliuM Chloride;Diphenyl iodine chloride salt;Dibenziodolium chloride, DPI;Diphenyleneiodoniumchloride(DPI);dibenzo[b,d]iodol-5-ium chloride
CBNumber
CB7355273
Molecular Formula
C12H8ClI
Formula Weight
314.55
MOL File
4673-26-1.mol
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DIPHENYLENEIODONIUM CHLORIDE Property

Melting point:
312-322 °C
storage temp. 
room temp
solubility 
Soluble in DMSO (up to 5 mg/ml with warming)
form 
Powder
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
29310099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D2926
Product name
Diphenyleneiodonium chloride
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2023/06/20
Sigma-Aldrich
Product number
D2926
Product name
Diphenyleneiodonium chloride
Purity
≥98%
Packaging
50mg
Price
$455
Updated
2023/06/20
Alfa Aesar
Product number
J64838
Product name
Diphenyleneiodonium chloride
Packaging
50mg
Price
$286
Updated
2023/06/20
Alfa Aesar
Product number
J64838
Product name
Diphenyleneiodonium chloride
Packaging
100mg
Price
$532
Updated
2023/06/20
Cayman Chemical
Product number
81050
Product name
Diphenyleneiodonium (chloride)
Purity
≥99%
Packaging
5mg
Price
$43
Updated
2023/06/20
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DIPHENYLENEIODONIUM CHLORIDE Chemical Properties,Usage,Production

Description

Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC50 = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC50 = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.

Chemical Properties

Crystalline Solid

Uses

Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Uses

Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Uses

Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Definition

ChEBI: An organic chloride salt having dibenziodolium as the counterion.

Biochem/physiol Actions

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

storage

Desiccate at -20°C

References

1) Stuehr?et al.?(1991),?Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J.,?5?98 2) Yea?et al.?(1990),?Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J.,?265?95 3) Ye?et al.?(2014),?Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther.,?349?4371 4) Mendes?et al.?(2001),?Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm.,?10?209 5) Kono?et al.?(2001),?Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat;?Am. J. Physiol. Gastrointest. Liver Physiol.,?280?G1005

DIPHENYLENEIODONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENYLENEIODONIUM CHLORIDE Suppliers

Belgium 1 Canada 1 China 112 Germany 2 India 1 Switzerland 1 United Kingdom 5 United States 15 Global 138
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40242
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15851
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 QQ:452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11716
Advantage
57
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
24707
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4860
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 18021002903
Fax
021-55068248
Email
3008007409@qq.com
Country
China
ProdList
4944
Advantage
60
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
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View Lastest Price from DIPHENYLENEIODONIUM CHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Hebei Yanxi Chemical Co., Ltd.
Product
DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price
US $40.00-40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-22
Career Henan Chemical Co
Product
DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-24

4673-26-1, DIPHENYLENEIODONIUM CHLORIDERelated Search:

Acetamidine hydrochloride DICHLOFLUANID Triethyl phosphate 4-tert-Butyltoluene 4'-tert-Butylacetophenone Polypropylenglycol diglycidyl ether Nitrite 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Food grade calcium chloride S-(-)-DPI-201-106,DPI-205-430 DPI DPI,DPI CHLORIDE,DIPHENYLENEIODONIUM CHLORIDE DPI-205-429,R-(+)-DPI-201-106 DPI 201-106 DPI CHLORIDE,DPI,DIPHENYLENEIODONIUM CHLORIDE DPI Dendrotoxin I (DTX-I), DPI DPI SULFATE

  • Diphenyleneiodonium chlorideDibenziodolium chloride
  • DiphenyleneiodoniuM chloride, 97+% 25MG
  • Dibenz[b,d]iodoliuM Chloride
  • DIBENZIODOLIUM CHLORIDE
  • DPI
  • Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem
  • Diphenyleneiodoniumchloride(DPI)
  • DPI CHLORIDE
  • DIPHENYLENEIODONIUM CHLORIDE
  • [1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE
  • Diphenyleneiodonium chloride, 97+%
  • Dibenziodolium chloride, DPI
  • benzo[b][1]benziodole hydrochloride
  • ibenziodoliumchloride
  • dibenzo[b,d]iodol-5-ium chloride
  • Diphenyl iodine chloride salt
  • 4673-26-1
  • C12H8ClI
  • C12H8ICl
  • BioChemical
  • Biochemicals and Reagents
  • L to O
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide Synthase
  • All Inhibitors
  • Inhibitors
  • Nitric Oxide Reagents
  • Nitric Oxide