DIPHENYLENEIODONIUM CHLORIDE

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DIPHENYLENEIODONIUM CHLORIDE

Product Name: DIPHENYLENEIODONIUM CHLORIDE
CAS No.: 4673-26-1
Chemical Name: DIPHENYLENEIODONIUM CHLORIDE
Synonyms: DPI;DPI CHLORIDE;ibenziodoliumchloride;DIBENZIODOLIUM CHLORIDE;DIPHENYLENEIODONIUM CHLORIDE;Dibenz[b,d]iodoliuM Chloride;Diphenyl iodine chloride salt;Dibenziodolium chloride, DPI;Diphenyleneiodoniumchloride(DPI);dibenzo[b,d]iodol-5-ium chloride
CBNumber: CB7355273
Molecular Formula: C12H8ClI
Formula Weight: 314.55
MOL File: 4673-26-1.mol

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DIPHENYLENEIODONIUM CHLORIDE Property

Melting point:: 312-322 °C
storage temp.: room temp
solubility: Soluble in DMSO (up to 5 mg/ml with warming)
form: Powder
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D2926
Product name: Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: D2926
Product name: Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 50mg
Price: $280.2
Updated: 2024/03/01

Alfa Aesar

Product number: J64838
Product name: Diphenyleneiodonium chloride
Packaging: 50mg
Price: $298
Updated: 2024/03/01

Alfa Aesar

Product number: J64838
Product name: Diphenyleneiodonium chloride
Packaging: 100mg
Price: $478.65
Updated: 2024/03/01

Cayman Chemical

Product number: 81050
Product name: Diphenyleneiodonium (chloride)
Purity: ≥99%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

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DIPHENYLENEIODONIUM CHLORIDE Chemical Properties,Usage,Production

Description

Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC₅₀ = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC₅₀ = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.

Chemical Properties

Crystalline Solid

Uses

Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Uses

Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Definition

ChEBI: An organic chloride salt having dibenziodolium as the counterion.

Biochem/physiol Actions

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

storage

Desiccate at -20°C

References

1) Stuehr?et al.?(1991),?Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J.,?5?98 2) Yea?et al.?(1990),?Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J.,?265?95 3) Ye?et al.?(2014),?Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther.,?349?4371 4) Mendes?et al.?(2001),?Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm.,?10?209 5) Kono?et al.?(2001),?Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat;?Am. J. Physiol. Gastrointest. Liver Physiol.,?280?G1005

DIPHENYLENEIODONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENYLENEIODONIUM CHLORIDE Suppliers

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View Lastest Price from DIPHENYLENEIODONIUM CHLORIDE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-22

Shaanxi Dideu Medichem Co. Ltd

Product: Diphenyleneiodonium chloride 4673-26-1
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-05

Hebei Mojin Biotechnology Co., Ltd

Product: DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

4673-26-1, DIPHENYLENEIODONIUM CHLORIDERelated Search:

4-tert-Butyltoluene 4'-tert-Butylacetophenone 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Acetamidine hydrochloride DICHLOFLUANID Triethyl phosphate Polypropylenglycol diglycidyl ether Food grade calcium chloride Nitrite DPI,DPI CHLORIDE,DIPHENYLENEIODONIUM CHLORIDE DPI DPI CHLORIDE,DPI,DIPHENYLENEIODONIUM CHLORIDE DPI 201-106 DPI SULFATE DPI S-(-)-DPI-201-106,DPI-205-430 Dendrotoxin I (DTX-I), DPI DPI-205-429,R-(+)-DPI-201-106

Diphenyleneiodonium chlorideDibenziodolium chloride

DiphenyleneiodoniuM chloride, 97+% 25MG

Dibenz[b,d]iodoliuM Chloride

DIBENZIODOLIUM CHLORIDE

DPI

Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

Diphenyleneiodoniumchloride(DPI)

DPI CHLORIDE

DIPHENYLENEIODONIUM CHLORIDE

[1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE

Diphenyleneiodonium chloride, 97+%

Dibenziodolium chloride, DPI

benzo[b][1]benziodole hydrochloride

ibenziodoliumchloride

dibenzo[b,d]iodol-5-ium chloride

Diphenyl iodine chloride salt

4673-26-1

C12H8ClI

C12H8ICl

BioChemical

Biochemicals and Reagents

L to O

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Nitric Oxide Synthase

All Inhibitors

Inhibitors

Nitric Oxide Reagents

Nitric Oxide