ChemicalBook > CAS DataBase List > DIPHENYLENEIODONIUM CHLORIDE

DIPHENYLENEIODONIUM CHLORIDE

Product Name: DIPHENYLENEIODONIUM CHLORIDE
CAS No.: 4673-26-1
Chemical Name: DIPHENYLENEIODONIUM CHLORIDE
Synonyms: DPI;DPI CHLORIDE;ibenziodoliumchloride;DIBENZIODOLIUM CHLORIDE;DIPHENYLENEIODONIUM CHLORIDE;Dibenz[b,d]iodoliuM Chloride;Diphenyl iodine chloride salt;Dibenziodolium chloride, DPI;Diphenyleneiodoniumchloride(DPI);dibenzo[b,d]iodol-5-ium chloride
CBNumber: CB7355273
Molecular Formula: C12H8ClI
Formula Weight: 314.55
MOL File: 4673-26-1.mol

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DIPHENYLENEIODONIUM CHLORIDE Property

Melting point:: 312-322 °C
storage temp.: room temp
solubility: Soluble in DMSO (up to 5 mg/ml with warming)
form: Powder
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI: InChI=1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
InChIKey: FCFZKAVCDNTYID-UHFFFAOYSA-M
SMILES: [I+]1C2=C(C=CC=C2)C2=C1C=CC=C2.[Cl-]

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D2926
Product name: Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 10mg
Price: $124
Updated: 2025/07/31

Sigma-Aldrich

Product number: D2926
Product name: Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 50mg
Price: $480
Updated: 2025/07/31

Sigma-Aldrich

Product number: 300260
Product name: Diphenyleneiodonium Chloride
Purity: A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).
Packaging: 10 mg
Price: $116
Updated: 2025/07/31

TCI Chemical

Product number: D6364
Product name: Dibenzo[b,d]iodol-5-ium Chloride
Packaging: 25MG
Price: $140
Updated: 2025/07/31

TCI Chemical

Product number: D6364
Product name: Dibenzo[b,d]iodol-5-ium Chloride
Packaging: 100MG
Price: $351
Updated: 2025/07/31

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DIPHENYLENEIODONIUM CHLORIDE Chemical Properties,Usage,Production

Description

Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC₅₀ = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC₅₀ = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.

Chemical Properties

Crystalline Solid

Uses

Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Uses

Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Definition

ChEBI: An organic chloride salt having dibenziodolium as the counterion.

Biochem/physiol Actions

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

storage

Desiccate at -20°C

References

[1] DENNIS J. STUEHR. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs1[J]. FASEB Journal, 1991, 5 1: 98-103. DOI:10.1096/fasebj.5.1.1703974
[2] C M YEA O T J A R Cross. Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.[J]. Biochemical Journal, 1990, 265 1: 95-100. DOI:10.1042/bj2650095
[3] CHENLI YE. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 349 3: 437-443. DOI:10.1124/jpet.114.213082
[4] Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species
[5] H. KONO. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2001, 73 1: G1005-12. DOI:10.1152/ajpgi.2001.280.5.g1005

DIPHENYLENEIODONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENYLENEIODONIUM CHLORIDE Suppliers

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View Lastest Price from DIPHENYLENEIODONIUM CHLORIDE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-22

Shaanxi Dideu Medichem Co. Ltd

Product: Diphenyleneiodonium chloride 4673-26-1
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-05

Career Henan Chemical Co

Product: DIPHENYLENEIODONIUM CHLORIDE 4673-26-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-24

4673-26-1, DIPHENYLENEIODONIUM CHLORIDERelated Search:

4-tert-Butyltoluene 4'-tert-Butylacetophenone 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Acetamidine hydrochloride DICHLOFLUANID Triethyl phosphate Polypropylenglycol diglycidyl ether Food grade calcium chloride Nitrite DPI,DPI CHLORIDE,DIPHENYLENEIODONIUM CHLORIDE DPI DPI CHLORIDE,DPI,DIPHENYLENEIODONIUM CHLORIDE DPI 201-106 DPI SULFATE DPI S-(-)-DPI-201-106,DPI-205-430 Dendrotoxin I (DTX-I), DPI DPI-205-429,R-(+)-DPI-201-106

Diphenyleneiodonium chlorideDibenziodolium chloride

DiphenyleneiodoniuM chloride, 97+% 25MG

Dibenz[b,d]iodoliuM Chloride

DIBENZIODOLIUM CHLORIDE

DPI

Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

Diphenyleneiodoniumchloride(DPI)

DPI CHLORIDE

DIPHENYLENEIODONIUM CHLORIDE

[1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE

Diphenyleneiodonium chloride, 97+%

Dibenziodolium chloride, DPI

benzo[b][1]benziodole hydrochloride

ibenziodoliumchloride

dibenzo[b,d]iodol-5-ium chloride

Diphenyl iodine chloride salt

Diphenyleneiodonium chloride, NO synthase

Diphenyleneiodonium chloride, 10 mM in DMSO

DPI (Diphenyleneiodonium chloride)

Diphenyleneiodonium chloride >=98%

4673-26-1

C12H8ClI

C12H8ICl

BioChemical

Biochemicals and Reagents

L to O

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Nitric Oxide Synthase

All Inhibitors

Inhibitors

Nitric Oxide Reagents

Nitric Oxide