4'-tert-Butylacetophenone
- Product Name
- 4'-tert-Butylacetophenone
- CAS No.
- 943-27-1
- Chemical Name
- 4'-tert-Butylacetophenone
- Synonyms
- 4-TERT-BUTYLACETOPHENONE;NSC 826;PHENOMUSCOL;ASISCHEM D29255;Ebastine Impurity 5;P-T-BUTYLACETOPHENONE;4'-t-Butylacetophenone;Ebastine EP Impurity B;Epastine EP Impurity B;p-tert-Butylacetophenon
- CBNumber
- CB3443929
- Molecular Formula
- C12H16O
- Formula Weight
- 176.25
- MOL File
- 943-27-1.mol
4'-tert-Butylacetophenone Property
- Melting point:
- 17-18 °C (dimorphic)(lit.)
- Boiling point:
- 107-108 °C5 mm Hg(lit.)
- Density
- 0.964 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.52(lit.)
- Flash point:
- 86 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Liquid
- Specific Gravity
- 0.964
- color
- Clear colorless
- Water Solubility
- insoluble
- Cosmetics Ingredients Functions
- PERFUMING
- InChI
- 1S/C12H16O/c1-9(13)10-5-7-11(8-6-10)12(2,3)4/h5-8H,1-4H3
- InChIKey
- UYFJYGWNYQCHOB-UHFFFAOYSA-N
- SMILES
- CC(=O)c1ccc(cc1)C(C)(C)C
- LogP
- 3.521 (est)
- CAS DataBase Reference
- 943-27-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]-(943-27-1)
- EPA Substance Registry System
- Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]- (943-27-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 10-36/37/38-20/21/22
- Safety Statements
- 16-29-33-36/37/39-26
- RIDADR
- UN 1224 3/PG 3
- WGK Germany
- 2
- TSCA
- TSCA listed
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29143990
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Flam. Liq. 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- S552089
- Product name
- 4'-(TERT-BUTYL)-ACETOPHENONE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- 357642
- Product name
- 4′-tert-Butylacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $105.45
- Updated
- 2025/07/31
- Product number
- S552089
- Product name
- 4'-(TERT-BUTYL)-ACETOPHENONE
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B6460
- Product name
- 4'-tert-Butylacetophenone
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $71
- Updated
- 2025/07/31
- Product number
- B6460
- Product name
- 4'-tert-Butylacetophenone
- Purity
- min. 95.0 %
- Packaging
- 25G
- Price
- $213
- Updated
- 2025/07/31
4'-tert-Butylacetophenone Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Uses
4'-tert-Butylacetophenone is used in the synthesis of 2-pyridone derivatives.
Uses
4′-tert-Butylacetophenone may be used in the synthesis of 2-pyridone derivatives and their fluorescence spectra has been evaluated.
Uses
4-tert-Butylacetophenone is an Impurity arising in the synthesis of Ebastine (E320000). Ebastine Impurity B.
General Description
4′-tert-Butylacetophenone is a para-substituted acetophenone.
Synthesis
p-Tert-butyl acetophenone was prepared as follows: in a 2 ml reaction vial 2-(4-(tert-butyl)phenyl)propan-2-ol (59.4 mg, 0.3 mmol), AgNO3 (1.6 mg, 3 mol%), Bi(OTf)3 (6 mg, 3 mol%) and K2S2O8 (245.8 mg. 3eq), and finally 2 wt% aqueous DAPGS-750-M (0.6 ml, 0.5 M) was added, followed by capping the reaction vial and stirring. After the stirring of the reaction solution, the reaction was extracted three times using ethyl acetate, and the organic phases of several extractions were combined into a 50 mL aubergine flask and processed for about 5 min using a Heidolph rotary evaporator with a rotational speed of 120 rpm, a temperature of 38 C, and a vacuum of 0.1 MPa, followed by column chromatography using a 200-mesh column chromatography silica gel with a unfolding agent of petroleum ether: ethyl acetate = 20: 1 Around, the target compound p-tert-butyl acetophenone was isolated. (42.8 mg, 81% yield, 98% purity by HPLC analysis, from the NMR profile, signal, noise, etc. can also reflect the product purity is very high).
4'-tert-Butylacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-tert-Butylacetophenone manufacturers
- Product
- 4'-tert-Butylacetophenone 943-27-1
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-12-09
- Product
- 4'-tert-Butylacetophenone 943-27-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- 4'-tert-Butylacetophenone 943-27-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-28