BAY 73-6691

Product Name: BAY 73-6691
CAS No.: 794568-92-6
Chemical Name: BAY 73-6691
Synonyms: (R)-BAY 73-6691;BAY 736691,BAY 73 6691;BAY 73-6691 >=98% (HPLC), powder;1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-(2-chlorophenyl)-1,5-dihydro-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-
CBNumber: CB2972181
Molecular Formula: C15H12ClF3N4O
Formula Weight: 356.73
MOL File: 794568-92-6.mol

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BAY 73-6691 Property

storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
color: off-white

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B3561
Product name: BAY 73-6691
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $241
Updated: 2025/07/31

Sigma-Aldrich

Product number: B3561
Product name: BAY 73-6691
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $759
Updated: 2025/07/31

TRC

Product number: B127603
Product name: BAY 73-6691
Packaging: 1mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0025654
Product name: BAY 73-6691
Purity: 99.85%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB159390
Product name: BAY 73-6691
Packaging: 10mg
Price: $225
Updated: 2021/12/16

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BAY 73-6691 Chemical Properties,Usage,Production

Uses

BAY 73-6691 has been used as a phosphodiesterase 9 inhibitor in ischemic heart samples and in structural studies. It may be used as a PDE 9 inhibitor in neuroblastoma?SH-SY5Y cells.

Biochem/physiol Actions

BAY 73-6691 was characterized in vitro as the first potent and selective inhibitor of phosphodiesterase 9 (PDE9), which is currently under preclinical development for the treatment of Alzheimer′s disease. This compound selectively inhibits human (IC50 = 55 nM) and murine (IC50 = 100 nM) PDE9 activity in vitro and shows only moderate activity against other cyclic nucleotide-specific phosphodiesterases. BAY 73-6691 alone did not significantly increase basal cGMP levels. The PDE9 inhibitor significantly potentiated the cGMP signals generated by sGC activating compounds such as BAY 58-2667 or 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine (BAY 41-2272) and induced leftward shifts of the corresponding concentration-response curves. The newly generated PDE9 reporter cell line show that BAY 73-6691 is able to efficiently penetrate cells and to inhibit intracellular PDE9 activity.

in vivo

BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ_25-35-injected mice on days 7 to 10 (day 7, F_(5,54)=65.153; day 8, F_(5,54)=62.340; day 9, F_(5,54)=37.529; day 10, F_(5,54)=38.624; P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. BAY 73-6691 dose-dependently elevates the Aβ_25-35-induced decrease of the dwell time on the 10th day post Aβ_25-35 injection (day 10, F_(5,54)=27.360, P<0.001). Results reveal that the Aβ_25-35 injection and BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. BAY 73-6691 alleviates Aβ_25-35-induced abnormalities of the above indices. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice. The BAY 73-6691 has no significant effect on the apoptosis of hippocampal neurons in sham mice^[1].

IC 50

PDE9

BAY 73-6691 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY 73-6691 Suppliers

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794568-92-6, BAY 73-6691Related Search:

1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one

(R)-BAY 73-6691

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-(2-chlorophenyl)-1,5-dihydro-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-

BAY 73-6691 >=98% (HPLC), powder

BAY 736691,BAY 73 6691

794568-92-6