BAY 73-6691
- Product Name
- BAY 73-6691
- CAS No.
- 794568-92-6
- Chemical Name
- BAY 73-6691
- Synonyms
- (R)-BAY 73-6691;BAY 736691,BAY 73 6691;BAY 73-6691 >=98% (HPLC), powder;1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-(2-chlorophenyl)-1,5-dihydro-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-
- CBNumber
- CB2972181
- Molecular Formula
- C15H12ClF3N4O
- Formula Weight
- 356.73
- MOL File
- 794568-92-6.mol
BAY 73-6691 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- color
- off-white
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B3561
- Product name
- BAY 73-6691
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $241
- Updated
- 2025/07/31
- Product number
- B3561
- Product name
- BAY 73-6691
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $759
- Updated
- 2025/07/31
- Product number
- B127603
- Product name
- BAY 73-6691
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CS-0025654
- Product name
- BAY 73-6691
- Purity
- 99.85%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FB159390
- Product name
- BAY 73-6691
- Packaging
- 10mg
- Price
- $225
- Updated
- 2021/12/16
BAY 73-6691 Chemical Properties,Usage,Production
Uses
BAY 73-6691 has been used as a phosphodiesterase 9 inhibitor in ischemic heart samples and in structural studies. It may be used as a PDE 9 inhibitor in neuroblastoma?SH-SY5Y cells.
Biochem/physiol Actions
BAY 73-6691 was characterized in vitro as the first potent and selective inhibitor of phosphodiesterase 9 (PDE9), which is currently under preclinical development for the treatment of Alzheimer′s disease. This compound selectively inhibits human (IC50 = 55 nM) and murine (IC50 = 100 nM) PDE9 activity in vitro and shows only moderate activity against other cyclic nucleotide-specific phosphodiesterases. BAY 73-6691 alone did not significantly increase basal cGMP levels. The PDE9 inhibitor significantly potentiated the cGMP signals generated by sGC activating compounds such as BAY 58-2667 or 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine (BAY 41-2272) and induced leftward shifts of the corresponding concentration-response curves. The newly generated PDE9 reporter cell line show that BAY 73-6691 is able to efficiently penetrate cells and to inhibit intracellular PDE9 activity.
in vivo
BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ25-35-injected mice on days 7 to 10 (day 7, F(5,54)=65.153; day 8, F(5,54)=62.340; day 9, F(5,54)=37.529; day 10, F(5,54)=38.624; P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. BAY 73-6691 dose-dependently elevates the Aβ25-35-induced decrease of the dwell time on the 10th day post Aβ25-35 injection (day 10, F(5,54)=27.360, P<0.001). Results reveal that the Aβ25-35 injection and BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. BAY 73-6691 alleviates Aβ25-35-induced abnormalities of the above indices. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice. The BAY 73-6691 has no significant effect on the apoptosis of hippocampal neurons in sham mice[1].
IC 50
PDE9
BAY 73-6691 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 73-6691 Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91