ChemicalBook > CAS DataBase List > DCP-LA

DCP-LA

Product Name
DCP-LA
CAS No.
28399-31-7
Chemical Name
DCP-LA
Synonyms
DCP-LA;FR 236924;DCP LA,DCPLA;2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoicacid;Cyclopropaneoctanoic acid, 2-[(2-pentylcyclopropyl)methyl]-;8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid;2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924
CBNumber
CB2973087
Molecular Formula
C20H36O2
Formula Weight
308.5
MOL File
28399-31-7.mol
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DCP-LA Property

Boiling point:
417.0±13.0 °C(Predicted)
Density 
0.968±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >2mg/mL
pka
4.78±0.10(Predicted)
form 
oil
color 
clear
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D5318
Product name
DCP-LA
Purity
≥95% (HPLC), oil
Packaging
1mg
Price
$227
Updated
2024/03/01
Sigma-Aldrich
Product number
D5318
Product name
DCP-LA
Purity
≥95% (HPLC), oil
Packaging
5mg
Price
$794
Updated
2022/05/15
Cayman Chemical
Product number
21375
Product name
DCP-LA
Purity
≥95%
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21375
Product name
DCP-LA
Purity
≥95%
Packaging
1mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
21375
Product name
DCP-LA
Purity
≥95%
Packaging
5mg
Price
$632
Updated
2024/03/01
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DCP-LA Chemical Properties,Usage,Production

Uses

FR 236924 is a PKCε activator, which may be useful as therapeutic agents for the treatment of Alzheimer disease as lowered PKCε activator levels are assocaited with Aβ degradation (a hallmark of Alzheimer’s disease).

Biological Activity

fr 236924 is a selective activator of pkc-ε [1].pkc is a monomeric ca2+- and phospholipid-dependent ser/thr protein kinase and plays an important role in growth factor-activated signaling and malignant transformation.fr 236924 (dcp-la) is a selective pkc-ε activator. in pc-12 cells, dcp-la (10 nm-100 μm) activated pkc in a concentration dependent way with the maximal effect at 100 nm. in the cell-free system, dcp-la (100 μm) significantly activated pkc-ε and exhibited >7-fold potency over other pkc isozymes (α,βi, βii, γ, δ, μ, η and ζ), suggesting that dcp-la was a selective pkc-ε activator. dcp-la exhibited the maximal effect on pkc-ε at 100 μm. the activation of pkc-ε induced by dcp-la (100 μm) was inhibited by dioleoyl-phosphatidylserine in a concentration dependent way, suggesting that dcp-la might bound to the phosphatidylserine binding site on pkc-ε. however, dioleoyl-phosphatidylserine increased dcp-la (100 μm)-induced pkc-ε activation in a concentration dependent way, suggesting a different activation mechanism [1]. in xenopus oocytes expressing α7 receptors, fr236924 (10 μm) induced a persistent increased α7 receptor responses to 144% via a pkc pathway. in rat hippocampal slices, fr236924 (10 nm to 10 μm) facilitated hippocampal neurotransmission [2].in the hippocampus of rats, fr236924 induced glutamate release and facilitated hippocampal synaptic transmission through pkc [3].

Biochem/physiol Actions

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

References

[1]. kanno t, yamamoto h, yaguchi t, et al. the linoleic acid derivative dcp-la selectively activates pkc-epsilon, possibly binding to the phosphatidylserine binding site. j lipid res, 2006, 47(6): 1146-1156.
[2]. tanaka a, nishizaki t. the newly synthesized linoleic acid derivative fr236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. bioorg med chem lett, 2003, 13(6): 1037-1040.
[3]. yamamoto s, kanno t, nagata t, et al. the linoleic acid derivative fr236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. neuroscience, 2005, 130(1): 207-213.

DCP-LA Preparation Products And Raw materials

Raw materials

Preparation Products

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DCP-LA Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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Sigma-Aldrich
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orderCN@merckgroup.com
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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88888888888
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hongquchem@qq.com
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MedBioPharmaceutical Technology Inc
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order@med-bio.cn
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Shanghai Universal Biotech Co.,Ltd
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Kaifeng Mingren Pharmaceutical Co.,LTD
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TargetMol Chemicals Inc.
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Nantong QuanYi Biotechnology Co., Ltd
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Shanghai Yifei Biotechnology Co. , Ltd.
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RD International Technology Co., Limited
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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Beijing Bolide Biotechnology Co., Ltd.
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Guangzhou Weijia Technology Co., Ltd.
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Shanghai Haoyang Biological Technology Co., Ltd.
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Absin Bioscience Inc.
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Boao Pike
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28399-31-7, DCP-LARelated Search:


  • DCP-LA
  • 2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924
  • 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoicacid
  • FR 236924
  • 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid
  • Cyclopropaneoctanoic acid, 2-[(2-pentylcyclopropyl)methyl]-
  • DCP LA,DCPLA
  • 28399-31-7