DCP-LA Property

Boiling point:

417.0±13.0 °C(Predicted)

Density 

0.968±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: >2mg/mL

pka

4.78±0.10(Predicted)

form 

oil

color 

clear

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DCP-LA Chemical Properties,Usage,Production

Uses

FR 236924 is a PKCε activator, which may be useful as therapeutic agents for the treatment of Alzheimer disease as lowered PKCε activator levels are assocaited with Aβ degradation (a hallmark of Alzheimer’s disease).

Biological Activity

fr 236924 is a selective activator of pkc-ε [1].pkc is a monomeric ca2+- and phospholipid-dependent ser/thr protein kinase and plays an important role in growth factor-activated signaling and malignant transformation.fr 236924 (dcp-la) is a selective pkc-ε activator. in pc-12 cells, dcp-la (10 nm-100 μm) activated pkc in a concentration dependent way with the maximal effect at 100 nm. in the cell-free system, dcp-la (100 μm) significantly activated pkc-ε and exhibited >7-fold potency over other pkc isozymes (α,βi, βii, γ, δ, μ, η and ζ), suggesting that dcp-la was a selective pkc-ε activator. dcp-la exhibited the maximal effect on pkc-ε at 100 μm. the activation of pkc-ε induced by dcp-la (100 μm) was inhibited by dioleoyl-phosphatidylserine in a concentration dependent way, suggesting that dcp-la might bound to the phosphatidylserine binding site on pkc-ε. however, dioleoyl-phosphatidylserine increased dcp-la (100 μm)-induced pkc-ε activation in a concentration dependent way, suggesting a different activation mechanism [1]. in xenopus oocytes expressing α7 receptors, fr236924 (10 μm) induced a persistent increased α7 receptor responses to 144% via a pkc pathway. in rat hippocampal slices, fr236924 (10 nm to 10 μm) facilitated hippocampal neurotransmission [2].in the hippocampus of rats, fr236924 induced glutamate release and facilitated hippocampal synaptic transmission through pkc [3].

Biochem/physiol Actions

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

References

[1]. kanno t, yamamoto h, yaguchi t, et al. the linoleic acid derivative dcp-la selectively activates pkc-epsilon, possibly binding to the phosphatidylserine binding site. j lipid res, 2006, 47(6): 1146-1156.
[2]. tanaka a, nishizaki t. the newly synthesized linoleic acid derivative fr236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. bioorg med chem lett, 2003, 13(6): 1037-1040.
[3]. yamamoto s, kanno t, nagata t, et al. the linoleic acid derivative fr236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. neuroscience, 2005, 130(1): 207-213.