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GRAVEOLINE

Product Name
GRAVEOLINE
CAS No.
485-61-0
Chemical Name
GRAVEOLINE
Synonyms
Rutamine;Graveoline, 10 mM in DMSO;2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one;4(1H)-Quinolinone,2-(1,3-benzodioxol-5-yl)-1-methyl-;1-methyl-2-[3',4'-(methylenedioxy)phenyl]-4-quinolone;2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
CBNumber
CB2981839
Molecular Formula
C17H13NO3
Formula Weight
279.29
MOL File
485-61-0.mol
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GRAVEOLINE Property

Melting point:
204-205 °C
Boiling point:
436.7±45.0 °C(Predicted)
Density 
1.327±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
1.74±0.70(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
G780015
Product name
Graveoline
Packaging
60mg
Price
$985
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016286
Product name
GRAVEOLINE
Purity
95.00%
Packaging
5MG
Price
$503.77
Updated
2021/12/16
Chemenu
Product number
CM260861
Product name
2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Purity
97%
Packaging
1g
Price
$608
Updated
2021/12/16
Crysdot
Product number
CD11117581
Product name
2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Purity
97%
Packaging
1g
Price
$644
Updated
2021/12/16
Alichem
Product number
485610
Product name
2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Packaging
1g
Price
$650
Updated
2021/12/16
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GRAVEOLINE Chemical Properties,Usage,Production

Uses

Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells.

Definition

ChEBI: Graveoline is a member of quinolines.

Synthesis

74054-38-9

74-88-4

485-61-0

Under nitrogen protection, 2-benzo[1,3]dioxol-5-yl-1H-quinolin-4-one (100 mg, 0.37 mmol) was dissolved in anhydrous N,N-dimethylformamide (5 mL) and stirred at room temperature. Potassium carbonate (156 mg, 1.1 mmol) and iodomethane (80 mg, 0.56 mmol) were added sequentially, and the reaction mixture was heated to 80 °C and stirred for 5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with ice water and extracted with dichloromethane (315 mL). The organic phase was dried with anhydrous sodium sulfate and the solvent was concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from ethyl acetate to give an off-white solid (100 mg, 95% yield). Melting point: 188.6-191.4°C. IR (KBr, cm?1): 1621, 1599, 1490, 1446, 1251, 1032, 751. mass spectrum (ESI): m/z 280.3 [M+H]? 1H NMR (400 MHz, CDCl?) δ (ppm): 3.60 (s, 3H), 5.99 (s, 1H), 6.14 (s, 2H), 7.02 (d, 1H, J=7.2 Hz), 7.08 (d, 1H, J=8.0 Hz), 7.17 (s, 1H), 7.42-7.46 (m, 1H), 7.79 ( d, 2H, J=3.6 Hz), 8.22 (d, 1H, J=8.0 Hz).13C NMR (100 MHz, CDCl?) δ (ppm): 37.35, 101.72, 108.64, 109.00, 112.64, 116.04, 122.76, 123.68, 126.68, 126.81, 129.43, 132.81 129.43, 132.37, 141.97, 147.94, 148.77, 154.44, 177.59.The 1H and 13C NMR data of the obtained products are in agreement with literature reports.

References

[1] Synthetic Communications, 2018, vol. 48, # 20, p. 2635 - 2641
[2] Synthetic Communications, 1996, vol. 26, # 3, p. 495 - 501

GRAVEOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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GRAVEOLINE Suppliers

China 58 India 1 United States 6 Global 65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
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View Lastest Price from GRAVEOLINE manufacturers

Honest Joy Holdings Limited
Product
2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one 485-61-0
Price
US $0.00/KG
Min. Order
1KG
Purity
97.2%
Supply Ability
100 tons
Release date
2022-01-17

485-61-0, GRAVEOLINERelated Search:

METANIL YELLOW METHYLENECYCLOHEXANE 2-PHENYL-1H-QUINOLIN-4-ONE 4-HYDROXY-2-METHYLQUINOLINE GRAVEOLINE

  • 1-methyl-2-[3',4'-(methylenedioxy)phenyl]-4-quinolone
  • 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
  • 2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one
  • 4(1H)-Quinolinone,2-(1,3-benzodioxol-5-yl)-1-methyl-
  • Rutamine
  • Graveoline, 10 mM in DMSO
  • 485-61-0