3'-METHOXYPHENACYL BROMIDE
- Product Name
- 3'-METHOXYPHENACYL BROMIDE
- CAS No.
- 5000-65-7
- Chemical Name
- 3'-METHOXYPHENACYL BROMIDE
- Synonyms
- NSC 405833;AKOS BBS-00003869;3'-MethoxyphenacyL;3-(BROMOACETYL)ANISOLE;M-METHOXYPHENACYL BROMIDE;3-METHOXYPHENACYL BROMIDE;m-Mehtoxyphenacyl Bromide;3'-Methoxyphenacyl Bromide;3'-MethoxyphenacylBromide>α-Bromo-m-methoxyacetophenone
- CBNumber
- CB3100727
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 5000-65-7.mol
3'-METHOXYPHENACYL BROMIDE Property
- Melting point:
- 60-62 °C(lit.)
- Boiling point:
- 215.8°C (rough estimate)
- Density
- 1.4921 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- color
- White to slightly yellow-green
- BRN
- 510128
- InChI
- InChI=1S/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
- InChIKey
- IOOHBIFQNQQUFI-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC(OC)=C1)CBr
- CAS DataBase Reference
- 5000-65-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Bromo-3'-methoxyacetophenone(5000-65-7)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-36/37-22
- Safety Statements
- 26-27-28-36/37/39-45-34
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 115673
- Product name
- 2-Bromo-3′-methoxyacetophenone
- Purity
- 98%
- Packaging
- 1g
- Price
- $19.81
- Updated
- 2025/07/31
- Product number
- 115673
- Product name
- 2-Bromo-3′-methoxyacetophenone
- Purity
- 98%
- Packaging
- 10g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- M0815
- Product name
- 3'-Methoxyphenacyl Bromide
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- A5505
- Product name
- 3'-Methoxyphenacyl Bromide [for HPLC Labeling]
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- 115673
- Product name
- 2-Bromo-3′-methoxyacetophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $236
- Updated
- 2025/07/31
3'-METHOXYPHENACYL BROMIDE Chemical Properties,Usage,Production
Chemical Properties
WHITE TO SLIGHTLY YELLOW-GREEN CRYST. POWDER
Uses
Derivatizing reagent.
Uses
2-bromo-3′-methoxyacetophenone, an alkylating agent, has been used to stabilize clopidogrel active metabolite (AM) in human plasma. It has also been used in the derivatisation of active metabolites in blood to ensure its stability during sample processing and storage.
Preparation
Obtained by reaction of bromine with 3-methoxyacetophenone in chloroform at 0° for 3 h (88%).
Synthesis
586-37-8
5000-65-7
General procedure for the synthesis of 2-bromo-3'-methoxyacetophenone from 3-methoxyacetophenone: To a stirred yellow solution of clarified 1-(3-methoxyphenyl)acetophenone (20 mL, 139 mmol) in tetrahydrofuran (250 mL) was added in batches of tribromobenzyltrimethylammonium (54.7 g, 145 mmol) and stirring was continued for 1 h at room temperature. After completion of the reaction, the ammonium salt was removed by filtration and the filter cake was washed with ether. Subsequently, the filtrate was concentrated under reduced pressure to give the oily product 2-bromo-1-(3-methoxyphenyl)ethanone (32.6 g, 142 mmol) which could be used without further purification in quantitative yield.
References
[1] Patent: WO2015/16729, 2015, A1. Location in patent: Page/Page column 30
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 22, p. 9239 - 9250
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 15, p. 5715 - 5723
[4] Journal of the Chemical Society of Pakistan, 2016, vol. 38, # 5, p. 859 - 863
[5] Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3354 - 3356
3'-METHOXYPHENACYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3'-METHOXYPHENACYL BROMIDE Suppliers
- Tel
- 0751-2838688 13376594225
- 1276075424@qq.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 010-60275820 13031183356
- Fax
- 010-60270825
- elainezt@sina.com
- Country
- China
- ProdList
- 1390
- Advantage
- 62
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
View Lastest Price from 3'-METHOXYPHENACYL BROMIDE manufacturers
- Product
- 3'-METHOXYPHENACYL BROMIDE 5000-65-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26