4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER

Product Name: 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
CAS No.: 28478-46-8
Chemical Name: 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
Synonyms: Methyl 4-hydroxy-o-anisate;Methyl 4-hydroxy-2-methoxybenzoate;4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 4-hydroxy-2-methoxy-, methyl ester
CBNumber: CB31010650
Molecular Formula: C9H10O4
Formula Weight: 182.18
MOL File: 28478-46-8.mol

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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Property

Melting point:: 150-151℃
storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M327263
Product name: Methyl4-Hydroxy-2-methoxybenzoate
Packaging: 250mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 2797AB
Product name: Methyl4-hydroxy-2-methoxybenzoate
Packaging: 250mg
Price: $173
Updated: 2021/12/16

Ambeed

Product number: A251096
Product name: Methyl4-Hydroxy-2-methoxybenzoate
Purity: 97%
Packaging: 100mg
Price: $64
Updated: 2021/12/16

Ambeed

Product number: A251096
Product name: Methyl4-Hydroxy-2-methoxybenzoate
Purity: 97%
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Ambeed

Product number: A251096
Product name: Methyl4-Hydroxy-2-methoxybenzoate
Purity: 97%
Packaging: 1g
Price: $235
Updated: 2021/12/16

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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4-?Hydroxy-?2-?methoxybenzoate is a reagent used in the synthesis of sphingosine-1-phosphate receptor agonist Ceralifimod used in the treatment of autoimmune diseases.

Synthesis

28478-45-7

28478-46-8

Step 3: A solution of EtOAc (200 mL) of methyl 2-methoxy-4-benzyloxybenzoate (40 g, 147 mmol) obtained in Step 2 was added to a Parr shaking flask, followed by 2 g of 10% Pd/C catalyst. The reaction mixture was placed in a Parr hydrogenation unit and shaken at 55 psi H2 pressure for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration under argon protection and the solvent was removed by distillation under reduced pressure. The resulting solid was washed with a small amount of EtOAc, filtered and dried under vacuum for 24 h to give methyl 2-methoxy-4-hydroxybenzoate in 99% yield.

References

[1] Patent: US5665719, 1997, A
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 21, p. 3081 - 3086
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1059 - 1062
[5] Journal of Medicinal Chemistry, 1985, vol. 28, # 6, p. 717 - 727

4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Suppliers

China 61 Germany 1 India 1 Ukraine 1 United States 9 Global 73

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View Lastest Price from 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER 28478-46-8
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

28478-46-8, 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTERRelated Search:

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Methyl 4-hydroxy-2-methoxybenzoate

Methyl 4-hydroxy-o-anisate

Benzoic acid, 4-hydroxy-2-methoxy-, methyl ester

4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER

28478-46-8