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Amonafide

Product Name
Amonafide
CAS No.
69408-81-7
Chemical Name
Amonafide
Synonyms
FA-142;AS1413;MFA-142;QuinaMed;Xanafide;AMONAFIDE;sc-207283;NSC-308847;Nafidimide;NCI 308847
CBNumber
CB31011071
Molecular Formula
C16H17N3O2
Formula Weight
283.33
MOL File
69408-81-7.mol
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Amonafide Property

Melting point:
162-164°C
Boiling point:
500.2±35.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.83±0.28(Predicted)
color 
Yellow to Dark Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2771
Product name
Amonafide
Purity
≥98% (HPLC)
Packaging
5MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2771
Product name
Amonafide
Purity
≥98% (HPLC)
Packaging
25MG
Price
$306
Updated
2024/03/01
TRC
Product number
A634205
Product name
Amonafide
Packaging
25mg
Price
$170
Updated
2021/12/16
Usbiological
Product number
002637
Product name
Amonafide
Packaging
10mg
Price
$410
Updated
2021/12/16
TRC
Product number
A634205
Product name
Amonafide
Packaging
100mg
Price
$430
Updated
2021/12/16
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Amonafide Chemical Properties,Usage,Production

Chemical Properties

Brownish Yellow Solid

Uses

Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent.

Definition

ChEBI: 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione is a member of isoquinolines.

Hazard

A poison

Biological Activity

amonafide is a novel topoisomerase ii inhibitor. topoisomerase ii plays critical roles including dna transcription, replication and chromosome segregation. though the biological functions of topoisomerase ii are important for insuring genomic integrity, the ability to interfere with topoisomerase ii and generate enzyme mediated dna damage is an effective strategy for cancer chemotherapy.

in vitro

amonafide intercalated with dna and disrupted the loading of topoisomerases. in contrast to the classic agents, amonafide was found to induce higher molecular weight fragmentation, resulting in the apoptosis without dna cleavage. amonafide was found to act in an atp-independent manner and seemed unlikely to induce the chromosome translocations associated with treatmentinduced leukemia [1].

in vivo

amonafide was found to be able to inhibit ip l1210 leukemia, with optimal increased life spans (ils) of 61% to 106% following single 16 mg/kg dosing on days 1 to 9. similar efficacy was noted against ip p388 murine leukemia and the sc implanted l1210 leukemia. additionally, amonafide demonstrated activity against two nonleukemic ip implanted murine tumors, the m5076 sarcoma and the b16 melanoma [2].

IC 50

4.67, 2.73, and 6.38 for ht-29, hela, and pc3 cells, respectively

References

[1] freeman cl,swords r,giles fj. amonafide: a future in treatment of resistant and secondary acute myeloid leukemia expert rev hematol.2012 feb;5(1):17-26.
[2] saez r,craig jb,kuhn jg,weiss gr,koeller j,phillips j,havlin k,harman g,hardy j,melink tj, et al. phase i clinical investigation of amonafide. j clin oncol.1989 sep;7(9):1351-8.

Amonafide Preparation Products And Raw materials

Raw materials

Preparation Products

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Amonafide Suppliers

Suzhou Wenzhi Biotechnology Co., Ltd.
Tel
13262848185
Email
20840032@qq.com
Country
China
ProdList
159
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4390
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
China Kouting Group Limited
Tel
+86 (21) 5811-6473 5811-6475
Fax
+86 (21) 6129-4103
Email
sales@koutingchina.com
Country
China
ProdList
496
Advantage
60
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View Lastest Price from Amonafide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Amonafide 69408-81-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Amonafide 69408-81-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

69408-81-7, AmonafideRelated Search:


  • AMONAFIDE DIHYDROCHLORIDE,1H-BENZ[DE]ISOQUINOLINE-1,3(2H)-DIONE, 5-AMINO-2-[2-(DIMETHYLAMINO)ETHYL]-
  • AMONAFIDE
  • 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-
  • 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
  • FA-142
  • MFA-142
  • Nafidimide
  • NSC-308847
  • 3-Amino-N-(2-dimethylaminoethyl)-1,8-naphthalimide
  • AS-1413(Amonafide)
  • MADE-FA 142
  • NCI 308847
  • AS1413
  • QuinaMed
  • Xanafide
  • AMonafide (AS1413)
  • sc-207283
  • AMonafide dihydrochloride
  • NSC308847,AS1413
  • Amonafide USP/EP/BP
  • 5-Amino-2-(2-(dimethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • Benzisoquinolinedione
  • 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
  • 69408-81-7
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals