Tandutinib

ChemicalBook > CAS DataBase List > Tandutinib

Product Name: Tandutinib
CAS No.: 387867-13-2
Chemical Name: Tandutinib
Synonyms: CS-309;MLN 518;CT 53518;NSC726292;Tandutinib;Unii-E1io3icj9a;CT53518; MLN518;Tandutinib(TINIBS);MLN518, Tandutinib;Tandutinib (MLN518)
CBNumber: CB31011758
Molecular Formula: C31H42N6O4
Formula Weight: 562.7
MOL File: 387867-13-2.mol

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Tandutinib Property

Melting point:: 177-178°C
Boiling point:: 769.5±60.0 °C(Predicted)
Density: 1.213±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 13.39±0.70(Predicted)
form: Solid
color: White to Off-White
CAS DataBase Reference: 387867-13-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2672
Product name: Tandutinib hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $60.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2672
Product name: Tandutinib hydrochloride
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: $98.4
Updated: 2024/03/01

Cayman Chemical

Product number: 12098
Product name: Tandutinib
Purity: ≥95%
Packaging: 25mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 12098
Product name: Tandutinib
Purity: ≥95%
Packaging: 50mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 12098
Product name: Tandutinib
Purity: ≥95%
Packaging: 100mg
Price: $140
Updated: 2024/03/01

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Tandutinib Chemical Properties,Usage,Production

Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC₅₀ = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC₅₀ = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

Chemical Properties

White Solid

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

Uses

antipsoratic

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML w hen administered in combination with cytarabine and daunorubicin.

Definition

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

target

c-Kit

References

[1] kelly lm1, yu jc, boulton cl, apatira m, li j, sullivan cm, williams i, amaral sm, curley dp, duclos n, neuberg d, scarborough rm, pandey a, hollenbach s, abe k, lokker na, gilliland dg, giese na. ct53518, a novel selective flt3 antagonist for the treatment of acute myelogenous leukemia (aml). cancer cell. 2002 jun;1(5):421-32.

Tandutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tandutinib manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Tandutinib 387867-13-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-25

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Tandutinib 387867-13-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-25

Dideu Industries Group Limited

Product: Tandutinib 387867-13-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

387867-13-2, TandutinibRelated Search:

5-Hydroxytryptophan Quizartinib (AC220) Linifanib (ABT-869) Dasatinib Masitinib PD 0332991 HCl Ibrutinib Bosutinib 6,7-DIMETHOXY-4-PIPERAZIN-1-YL-QUINAZOLINE Tandutinib

Tandutinib

1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-

4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide

Unii-E1io3icj9a

Tandutinib(CT 53518)

Tandutinib (MLN518)

CT53518; MLN518

Tandutinib(TINIBS)

(4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide

4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide

CT 53518

MLN 518

Tandutinib for research

N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide

NSC726292

(4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518)

4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]-

N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-

MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518;

Tandutinib (CT53518, MLN518)

CS-309

Tandutinib（MLN518, CT53518）

Tandutinib USP/EP/BP

Tandutinib (MLN518, CT53518, NSC-726292)

4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(...

MLN518, Tandutinib

Tandutinib CT53518 MLN518 CT-53518 MLN-518

387867-13-2

C31H42N6O4

C27H31Br2ClN4O2

Inhibitors

ZUBRIN

API

Intermediates & Fine Chemicals

Pharmaceuticals

Tyrosine Kinase Inhibitors