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Tandutinib

Product Name
Tandutinib
CAS No.
387867-13-2
Chemical Name
Tandutinib
Synonyms
CS-309;MLN 518;CT 53518;CID 3231;NSC726292;Tandutinib;Unii-E1io3icj9a;CT53518; MLN518;Tandutinib(TINIBS);MLN518, Tandutinib
CBNumber
CB31011758
Molecular Formula
C31H42N6O4
Formula Weight
562.7
MOL File
387867-13-2.mol
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Tandutinib Property

Melting point:
177-178°C
Boiling point:
769.5±60.0 °C(Predicted)
Density 
1.213±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.39±0.70(Predicted)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
387867-13-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2672
Product name
Tandutinib hydrochloride
Purity
≥98% (HPLC)
Packaging
25MG
Price
$60.7
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2672
Product name
Tandutinib hydrochloride
Purity
≥98% (HPLC)
Packaging
100MG
Price
$98.4
Updated
2024/03/01
Cayman Chemical
Product number
12098
Product name
Tandutinib
Purity
≥95%
Packaging
25mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
12098
Product name
Tandutinib
Purity
≥95%
Packaging
50mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
12098
Product name
Tandutinib
Purity
≥95%
Packaging
100mg
Price
$140
Updated
2024/03/01
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Tandutinib Chemical Properties,Usage,Production

Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

Chemical Properties

White Solid

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

Uses

antipsoratic

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML w hen administered in combination with cytarabine and daunorubicin.

Definition

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

target

c-Kit

References

[1] kelly lm1, yu jc, boulton cl, apatira m, li j, sullivan cm, williams i, amaral sm, curley dp, duclos n, neuberg d, scarborough rm, pandey a, hollenbach s, abe k, lokker na, gilliland dg, giese na. ct53518, a novel selective flt3 antagonist for the treatment of acute myelogenous leukemia (aml). cancer cell. 2002 jun;1(5):421-32.

Tandutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Tandutinib Suppliers

Canada 1 China 134 Europe 1 Germany 1 India 3 The Netherlands 1 United Kingdom 4 United States 26 Global 171
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Tandutinib manufacturers

Sinoway Industrial co., ltd.
Product
Tandutinib 387867-13-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-06-07
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Tandutinib 387867-13-2
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-25
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Tandutinib 387867-13-2
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-25

387867-13-2, TandutinibRelated Search:

5-Hydroxytryptophan Quizartinib (AC220) Linifanib (ABT-869) Dasatinib Masitinib PD 0332991 HCl Ibrutinib Bosutinib 6,7-DIMETHOXY-4-PIPERAZIN-1-YL-QUINAZOLINE Tandutinib

  • Tandutinib
  • 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
  • 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide
  • Unii-E1io3icj9a
  • Tandutinib(CT 53518)
  • Tandutinib (MLN518)
  • CT53518; MLN518
  • Tandutinib(TINIBS)
  • (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
  • 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
  • 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
  • CT 53518
  • MLN 518
  • Tandutinib for research
  • N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide
  • NSC726292
  • (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518)
  • 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]-
  • N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-
  • MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518;
  • Tandutinib (CT53518, MLN518)
  • CS-309
  • Tandutinib（MLN518, CT53518）
  • Tandutinib USP/EP/BP
  • Tandutinib (MLN518, CT53518, NSC-726292)
  • 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(...
  • MLN518, Tandutinib
  • Tandutinib CT53518 MLN518 CT-53518 MLN-518
  • CID 3231
  • 387867-13-2
  • C31H42N6O4
  • C27H31Br2ClN4O2
  • Inhibitors
  • ZUBRIN
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors