Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)
- Product Name
- Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)
- CAS No.
- 405230-79-7
- Chemical Name
- Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)
- Synonyms
- Pyridine,2-chloro-5-fluoro-, 1-oxide;2-chloro-5-fluoro-1-oxidopyridin-1-ium;Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI)
- CBNumber
- CB31046909
- Molecular Formula
- C5H3ClFNO
- Formula Weight
- 147.53
- MOL File
- 405230-79-7.mol
Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) Property
- Melting point:
- 98-100℃
- Boiling point:
- 311.3±22.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.34±0.10(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585785
- Product name
- 2-Chloro-5-fluoropyridine-N-oxide
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- HCH0363543
- Product name
- 2-CHLORO-5-FLUOROPYRIDINE-1-OXIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.7
- Updated
- 2021/12/16
- Product number
- 085210
- Product name
- 2-Chloro-5-fluoropyridine 1-oxide
- Purity
- 97%
- Packaging
- 1g
- Price
- $524
- Updated
- 2021/12/16
- Product number
- 5485AB
- Product name
- 2-Chloro-5-fluoropyridine1-oxide
- Packaging
- 10g
- Price
- $652
- Updated
- 2021/12/16
- Product number
- A673254
- Product name
- 2-Chloro-5-fluoropyridine1-oxide
- Purity
- 97%
- Packaging
- 25g
- Price
- $743
- Updated
- 2021/12/16
Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) Chemical Properties,Usage,Production
Synthesis
31301-51-6
405230-79-7
General procedure: 2-chloro-5-fluoropyridine (20 g, 152 mmol) was dissolved in trifluoroacetic acid (150 mL) under nitrogen protection. Hydrogen peroxide (78 mL, 760 mmol) was slowly added to the solution at 70°C. The reaction mixture was stirred at 70°C for 16 hours. Upon completion of the reaction, the reaction solution was concentrated. Water and dichloromethane (DCM) were added to the residue. The pH was adjusted to 7 with 28% ammonium hydroxide solution and then extracted with DCM. The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated to give 2-chloro-5-fluoropyridine 1-oxide (20.1 g, 136 mmol, 90% yield), and the product could be used in the next reaction without further purification.LC-MS analysis showed m/z 147.6 (M+H) with retention time of 0.78 min.
References
[1] Patent: WO2016/203401, 2016, A1. Location in patent: Page/Page column 191
[2] Patent: WO2011/113802, 2011, A2. Location in patent: Page/Page column 106
[3] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 12, p. 1975 - 2000
[4] Patent: US2004/116362, 2004, A1. Location in patent: Page/Page column 12; Figure 1
[5] Patent: US2012/95031, 2012, A1. Location in patent: Page/Page column 158-159
Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) manufacturers
- Product
- Pyridine, 2-chloro-5-fluoro-, 1-oxide (9CI) 405230-79-7
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09