Sotevtamab
- Product Name
- Sotevtamab
- CAS No.
- 2411526-47-9
- Chemical Name
- Sotevtamab
- Synonyms
- Sotevtamab;AB-16B5 (anti-Clusterin);Research Grade Sotevtamab;Research Grade Sotevtamab (DHC84101)
- CBNumber
- CB310617093
- Formula Weight
- 0
- MOL File
- Mol file
Sotevtamab Property
- form
- Liquid
- color
- Colorless to light yellow
Sotevtamab Chemical Properties,Usage,Production
Uses
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research[1][2][3].
in vivo
Sotevtamab (10 and 50 mg/kg，i.v.) is well tolerated and shows no signs of toxicity in monkeys[3].
References
[1] Gilles Tremblay, et al. Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition. Cancer Res 15 April 2010; 70 (8_Supplement): 1467.
[2] Cristiano Ferrario, et al. Phase 1 first-in-human study of anti-clusterin antibody AB-16B5 in patients with advanced solid malignancies. Cancer Res 1 July 2017; 77 (13_Supplement): CT098.
[3] Gilles B. et al. Pre-clinical evaluation of AB-16B5, a monoclonal antibody specific for tumor-associated sCLU, demonstrates therapeutic potential as an inhibitor of EMT in prostate, pancreatic and lung cancer. Cancer Res 15 April 2011; 71 (8_Supplement): LB–33.
Sotevtamab Preparation Products And Raw materials
Raw materials
Preparation Products
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