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4-METHYLPYRAZOLE HYDROCHLORIDE

Product Name
4-METHYLPYRAZOLE HYDROCHLORIDE
CAS No.
56010-88-9
Chemical Name
4-METHYLPYRAZOLE HYDROCHLORIDE
Synonyms
FOMEPIZOLE HYDROCHLORIDE;4-METHYLPYRAZOLE HYDROCHLORIDE;Fomepizole/FomepizolechlorideHCl;4-Methyl-1H-pyrazole hydrochloride;4-Methylpyrazole hydrochloride alcohol dehydrogenase inhibitor
CBNumber
CB3106840
Molecular Formula
C4H7ClN2
Formula Weight
118.56
MOL File
56010-88-9.mol
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4-METHYLPYRAZOLE HYDROCHLORIDE Property

Melting point:
157-159 °C
storage temp. 
2-8°C
solubility 
methanol: 100mg/mL, clear, colorless to yellow
form 
powder
color 
Purple to purplish red
biological source
synthetic (organic)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1387
Product name
4-Methylpyrazole hydrochloride
Purity
alcohol dehydrogenase inhibitor
Packaging
100mg
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
M1387
Product name
4-Methylpyrazole hydrochloride
Purity
alcohol dehydrogenase inhibitor
Packaging
1g
Price
$884
Updated
2025/07/31
Sigma-Aldrich
Product number
M1387
Product name
4-Methylpyrazole hydrochloride
Purity
alcohol dehydrogenase inhibitor
Packaging
500mg
Price
$518
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
CHM0115061
Product name
4-METHYLPYRAZOLE HYDROCHLORIDE
Purity
95.00%
Packaging
100MG
Price
$634.02
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0115061
Product name
4-METHYLPYRAZOLE HYDROCHLORIDE
Purity
95.00%
Packaging
500MG
Price
$838.02
Updated
2021/12/16
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4-METHYLPYRAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

4-Methylpyrazole hydrochloride has been used:

  • as a cytochrome P450 2E1 inhibitor
  • as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
  • to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.

in vivo

Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4]

Animal Model:Male CD-1 mice weighing 18-25 g[4]
Dosage:25 mg/kg
Administration:IP; single dose
Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).

IC 50

CYP2E1

4-METHYLPYRAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYLPYRAZOLE HYDROCHLORIDE Suppliers

China 19 Germany 1 Sweden 1 Switzerland 1 United Kingdom 1 United States 7 Global 30
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，
Tel
028-83243028 19136088901
Email
sinostandards@163.com
Country
China
ProdList
4976
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58

56010-88-9, 4-METHYLPYRAZOLE HYDROCHLORIDERelated Search:

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE (-)-QUINPIROLE HYDROCHLORIDE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE Dichlorosulfophenyl-3-methylpyrazolone 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 4-Methylpyrazole ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID 1-(3-CHLOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID HYDRAZIDE 4-METHYLPYRAZOLE HYDROCHLORIDE 5-AMINO-1-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-CHLORO-3-[2-(DIMETHYLAMINO)-1-FORMYLVINYL]-1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE

  • FOMEPIZOLE HYDROCHLORIDE
  • 4-METHYLPYRAZOLE HYDROCHLORIDE
  • Fomepizole/FomepizolechlorideHCl
  • 4-Methyl-1H-pyrazole hydrochloride
  • 4-Methylpyrazole hydrochloride alcohol dehydrogenase inhibitor
  • 56010-88-9
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Alcohol dehydrogenase human
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme