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BIM187

Product Name
BIM187
CAS No.
137734-88-4
Chemical Name
BIM187
Synonyms
BIM187;1-Phe-8-Leu-9-Leu-litorin-NH2;L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI)
CBNumber
CB31073336
Molecular Formula
C53H76N14O10
Formula Weight
1069.26
MOL File
137734-88-4.mol
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BIM187 Property

storage temp. 
Store at -20°C
solubility 
Soluble to 2 mg/ml in H2O
form 
solid
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
254759
Product name
BIM 187
Packaging
1mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0004452
Product name
BIM 187
Purity
95.00%
Packaging
5MG
Price
$500.96
Updated
2021/12/16
ApexBio Technology
Product number
B5330
Product name
BIM187
Packaging
1mg
Price
$314
Updated
2021/12/16
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BIM187 Chemical Properties,Usage,Production

Biological Activity

bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors including one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 187is a new peptide of bombesin while bim 189 is a potent bombesin antagonis.

in vitro

bombesin stimulates mainly the bombesin high-affinity receptor, and bim 187 ([d-phe i ,leu 8'9 ]litorin-nhe), a new bombesin agonist, stimulates the bombesin/grp receptor type. [2].

in vivo

to study the mechanism by which bombesin induces satiety, we studied the effect of bim187 on food intake in rats fed 6 h a day. bim 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187 [2].

References

[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim187) and a new antagonist (bim189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8.

BIM187 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIM187 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4814
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
13774214275
Email
zhouzz@univ-bio.com
Country
China
ProdList
24994
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6659
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4600
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4988
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58
Changsha MOL Changes Biotechnology Co., Ltd.
Tel
+8619375158599
Email
info@molchanges.com
Country
China
ProdList
5223
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58
Zhejiang Hangyu API Co., Ltd
Tel
+8617531972939
Email
anna@api-made.com
Country
China
ProdList
2943
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58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58

137734-88-4, BIM187Related Search:


  • BIM187
  • 1-Phe-8-Leu-9-Leu-litorin-NH2
  • L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI)
  • 137734-88-4
  • C53H76N14O10