BIM187
- Product Name
- BIM187
- CAS No.
- 137734-88-4
- Chemical Name
- BIM187
- Synonyms
- BIM187;1-Phe-8-Leu-9-Leu-litorin-NH2;L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI)
- CBNumber
- CB31073336
- Molecular Formula
- C53H76N14O10
- Formula Weight
- 1069.26
- MOL File
- 137734-88-4.mol
BIM187 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 2 mg/ml in H2O
- form
- solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 254759
- Product name
- BIM 187
- Packaging
- 1mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- PEP0004452
- Product name
- BIM 187
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.96
- Updated
- 2021/12/16
- Product number
- B5330
- Product name
- BIM187
- Packaging
- 1mg
- Price
- $314
- Updated
- 2021/12/16
BIM187 Chemical Properties,Usage,Production
Biological Activity
bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors including one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 187is a new peptide of bombesin while bim 189 is a potent bombesin antagonis.
in vitro
bombesin stimulates mainly the bombesin high-affinity receptor, and bim 187 ([d-phe i ,leu 8'9 ]litorin-nhe), a new bombesin agonist, stimulates the bombesin/grp receptor type. [2].
in vivo
to study the mechanism by which bombesin induces satiety, we studied the effect of bim187 on food intake in rats fed 6 h a day. bim 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187 [2].
References
[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim187) and a new antagonist (bim189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8.
BIM187 Preparation Products And Raw materials
Raw materials
Preparation Products
BIM187 Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- +86-17380623303 +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4814
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6968
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24994
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6659
- Advantage
- 58
- Tel
- 19961912513
- sales@hongtide.com
- Country
- China
- ProdList
- 4600
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- +8617531972939
- anna@api-made.com
- Country
- China
- ProdList
- 2943
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@advtechind.com
- Country
- United States
- ProdList
- 6075
- Advantage
- 58