BIM187
- Product Name
- BIM187
- CAS No.
- 137734-88-4
- Chemical Name
- BIM187
- Synonyms
- BIM187;1-Phe-8-Leu-9-Leu-litorin-NH2;L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI)
- CBNumber
- CB31073336
- Molecular Formula
- C53H76N14O10
- Formula Weight
- 1069.26
- MOL File
- 137734-88-4.mol
BIM187 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 2 mg/ml in H2O
- form
- solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 254759
- Product name
- BIM 187
- Packaging
- 1mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- B5330
- Product name
- BIM187
- Packaging
- 1mg
- Price
- $314
- Updated
- 2021/12/16
- Product number
- PEP0004452
- Product name
- BIM 187
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.96
- Updated
- 2021/12/16
BIM187 Chemical Properties,Usage,Production
Biological Activity
bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors including one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 187is a new peptide of bombesin while bim 189 is a potent bombesin antagonis.
in vitro
bombesin stimulates mainly the bombesin high-affinity receptor, and bim 187 ([d-phe i ,leu 8'9 ]litorin-nhe), a new bombesin agonist, stimulates the bombesin/grp receptor type. [2].
in vivo
to study the mechanism by which bombesin induces satiety, we studied the effect of bim187 on food intake in rats fed 6 h a day. bim 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187 [2].
References
[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim187) and a new antagonist (bim189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8.
BIM187 Preparation Products And Raw materials
Raw materials
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