Marimastat
- Product Name
- Marimastat
- CAS No.
- 154039-60-8
- Chemical Name
- Marimastat
- Synonyms
- TMH;GI 5712;BB 2516;TA 2516;CS-1627;KB-R 8898;Marimastat;Marimistat;Marimastat(BB-2516);BB 2516; MARIMISTAT
- CBNumber
- CB31073538
- Molecular Formula
- C15H29N3O5
- Formula Weight
- 331.41
- MOL File
- 154039-60-8.mol
Marimastat Property
- Melting point:
- 148℃
- Density
- 1.140±0.06 g/cm3(Predicted)
- RTECS
- EJ6665000
- storage temp.
- -20°C
- solubility
- DMSO: ≥20mg/mL
- form
- White solid
- pka
- 9.44±0.40(Predicted)
- color
- White to gray
Safety
- WGK Germany
- 3
- HS Code
- 29241990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2699
- Product name
- Marimastat
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- 444289
- Product name
- Marimastat
- Packaging
- 5mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- J67288
- Product name
- Marimastat, 98%
- Packaging
- 1mg
- Price
- $126
- Updated
- 2023/06/20
- Product number
- J67288
- Product name
- Marimastat, 98%
- Packaging
- 10mg
- Price
- $286
- Updated
- 2023/06/20
- Product number
- 14869
- Product name
- Marimastat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Marimastat Chemical Properties,Usage,Production
Uses
Antineoplastic (matrix metalloproteinase inhibitor).
Uses
Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.
Uses
Marimastat has been used as an inhibitor of:
- metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
- metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
- metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10
Definition
ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.
General Description
An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
Biological Activity
Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.
Biochem/physiol Actions
Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor
storage
Store at -20°C
Marimastat Preparation Products And Raw materials
Raw materials
Preparation Products
Marimastat Suppliers
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- Fax
- 86-21-57758967
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- Country
- China
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- 2922
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- 010-82848833 400-666-7788
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- 86-10-82849933
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- China
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- 821-50328103-801 18930552037
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- 86-21-50328109
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- China
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- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
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- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
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- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
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- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
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- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
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- Country
- China
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- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
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View Lastest Price from Marimastat manufacturers
- Product
- Marimastat 154039-60-8
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-14
- Product
- Marimastat 154039-60-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Marimastat 154039-60-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09