ChemicalBook > CAS DataBase List > Marimastat

Marimastat

Product Name
Marimastat
CAS No.
154039-60-8
Chemical Name
Marimastat
Synonyms
TMH;GI 5712;BB 2516;TA 2516;CS-1627;KB-R 8898;Marimastat;Marimistat;Marimastat(BB-2516);BB 2516; MARIMISTAT
CBNumber
CB31073538
Molecular Formula
C15H29N3O5
Formula Weight
331.41
MOL File
154039-60-8.mol
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Marimastat Property

Melting point:
148℃
Density 
1.140±0.06 g/cm3(Predicted)
RTECS 
EJ6665000
storage temp. 
-20°C
solubility 
DMSO: ≥20mg/mL
form 
White solid
pka
9.44±0.40(Predicted)
color 
White to gray
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Safety

WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2699
Product name
Marimastat
Purity
≥98% (HPLC)
Packaging
5mg
Price
$221
Updated
2024/03/01
Sigma-Aldrich
Product number
444289
Product name
Marimastat
Packaging
5mg
Price
$289
Updated
2024/03/01
Alfa Aesar
Product number
J67288
Product name
Marimastat, 98%
Packaging
1mg
Price
$126
Updated
2023/06/20
Alfa Aesar
Product number
J67288
Product name
Marimastat, 98%
Packaging
10mg
Price
$286
Updated
2023/06/20
Cayman Chemical
Product number
14869
Product name
Marimastat
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
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Marimastat Chemical Properties,Usage,Production

Uses

Antineoplastic (matrix metalloproteinase inhibitor).

Uses

Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.

Uses

Marimastat has been used as an inhibitor of:

  • metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
  • metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
  • metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10

Definition

ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.

General Description

An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.

Biological Activity

Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.

Biochem/physiol Actions

Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor

storage

Store at -20°C

Marimastat Preparation Products And Raw materials

Raw materials

Preparation Products

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Marimastat Suppliers

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View Lastest Price from Marimastat manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Marimastat 154039-60-8
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Marimastat 154039-60-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Marimastat 154039-60-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

154039-60-8, MarimastatRelated Search:

Cilastatin Marimastat HEXANOHYDROXAMIC ACID L-TERT-LEUCINE METHYLAMIDE

  • Marimastat
  • (2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-dihydroxy-2-isobutylsuccinamide
  • (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
  • (2R,3S)-N1-((S)-3,3-diMethyl-1-(MethylaMino)-1-oxobutan-2-yl)-N4
  • BB 2516
  • GI 5712
  • KB-R 8898
  • TA 2516
  • Marimastat(BB-2516)
  • BB2516, (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl] propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
  • (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N\',3-dihydroxy-2-(2-methylpropyl)butanediamide
  • BB 2516; MARIMISTAT
  • Marimistat
  • CS-1627
  • Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-
  • TMH
  • BB2516|||KB-R8898|||TA2516
  • Marimastat, Matrix metalloprotease (MMP) inhibitor
  • Marimastat, 10 mM in DMSO
  • 154039-60-8
  • C15H29N3O5
  • API