Fexaramine

Product Name: Fexaramine
CAS No.: 574013-66-4
Chemical Name: Fexaramine
Synonyms: CS-1691;Depasan;Actospar;Fexaramine;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr;(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester
CBNumber: CB31074393
Molecular Formula: C32H36N2O3
Formula Weight: 496.64
MOL File: 574013-66-4.mol

More

Less

Fexaramine Property

Boiling point:: 677.7±55.0 °C(Predicted)
Density: 1.158±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 50 mg/mL (100.68 mM; Need ultrasonic)
form: powder
pka: 4.95±0.24(Predicted)
color: white to beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1390
Product name: Fexaramine
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $142
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1390
Product name: Fexaramine
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $564
Updated: 2023/06/20

Cayman Chemical

Product number: 17369
Product name: Fexaramine
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17369
Product name: Fexaramine
Purity: ≥98%
Packaging: 5mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 17369
Product name: Fexaramine
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

More

Less

Fexaramine Chemical Properties,Usage,Production

Description

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC₅₀ = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (; EC₅₀ = 80 nM). Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.

Uses

Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model.

Definition

ChEBI: Fexaramine is a member of biphenyls.

General Description

Fexaramine belongs to the nuclear hormone receptor family.

Biological Activity

Potent, selective farnesoid X receptor agonist (EC 50 = 25 nM). Displays no activity at hRXR α , hPPAR α , hPPAR γ , hPPAR δ , mPXR, hPXR, hLXR α , hTR β , hRAR β , mCAR, mERR γ and hVDR receptors.

Biochem/physiol Actions

Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.

storage

Desiccate at +4°C

Fexaramine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Fexaramine Suppliers

China 74 Germany 1 India 2 United Kingdom 1 United States 14 Global 92

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973 13515979683
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1079
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

More

Less

View Lastest Price from Fexaramine manufacturers

Career Henan Chemical Co

Product: Fexaramine 574013-66-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

574013-66-4, FexaramineRelated Search:

RGB-286638 (free base) GSK2141795 SR9009 TD52 BAM15 (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide TG4-155 PH 797804 NVP-TAE684 Fexaramine

Fexaramine

3-[3-[(Cyclohexylcarbonyl)[[4\'-(dimethylamino)[1,1\'-biphenyl]-4-yl]methyl]amino]phenyl]-2-Propenoic acid methyl ester, >98%

CS-1691

3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester

2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]aMino]phenyl]-, Methyl ester

(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate

(2E,4Z)-5-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)-4-(methoxycarbonyl)penta-2,4-dienoic acid

3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr

2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester, (2E)-

Actospar

Depasan

(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate

Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate

574013-66-4

C32H36N2O3

Inhibitors